Hug Nele, Longman Dasa, Cáceres Javier F
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
Nucleic Acids Res. 2016 Feb 29;44(4):1483-95. doi: 10.1093/nar/gkw010. Epub 2016 Jan 14.
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response.
无义介导的mRNA衰变（NMD）途径选择性地降解含有提前终止密码子（PTC）的mRNA，但也调节大量细胞RNA的丰度。NMD在基因表达控制中的核心作用需要存在紧密调节该途径强度的缓冲机制。在这里，我们将重点关注NMD的机制，重点是RNA解旋酶在从识别PTC的NMD复合物转变为促进mRNA衰变的复合物过程中的作用。我们还将回顾旨在揭示新型反式作用因子及其在NMD途径中的功能作用的最新策略。最后，我们将描述NMD反应生理作用研究的最新进展。
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