Lewis R V, McLay J, Maclean D, Tregaskis B
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
J Hum Hypertens. 1989 Aug;3(4):233-7.
Twelve patients (mean age 48.8 years, 5 females) with untreated labile or mild essential hypertension completed a randomised, double-blind crossover study comparing the effects of two-week courses of indomethacin, sulindac and matching placebo upon sitting and standing blood pressure. Both indomethacin and sulindac significantly increased systolic BP when compared with placebo; indomethacin tended to have a greater pressor effect than sulindac. During treatment with indomethacin, the mean BP rose from 136/86 to 149/92 (sitting), and from 136/93 to 150/99 standing. The extent of the pressor response was unrelated to baseline BP. The results indicate that both non-steroidal anti-inflammatory drugs (NSAIDs) have a significant pressor effect in individuals with untreated labile or mild hypertension. The fact that sulindac had a pressor effect implies that this response may be unrelated to inhibition of renal prostaglandins, or that the renal-sparing effect of sulindac is only relative. Extra-renal prostaglandins may play a role in the control of BP in this population. Individuals with labile or mild hypertension do not appear to exhibit exaggerated pressor responses during treatment with these NSAIDs, as similar increases in BP have been reported in normal subjects.
12例未经治疗的不稳定型或轻度原发性高血压患者（平均年龄48.8岁，5名女性）完成了一项随机、双盲交叉研究，比较了消炎痛、舒林酸两周疗程及匹配安慰剂对坐位和立位血压的影响。与安慰剂相比，消炎痛和舒林酸均显著升高收缩压；消炎痛的升压作用往往比舒林酸更强。在消炎痛治疗期间，平均血压从坐位时的136/86升至149/92，立位时从136/93升至150/99。升压反应的程度与基线血压无关。结果表明，两种非甾体抗炎药（NSAIDs）对未经治疗的不稳定型或轻度高血压患者均有显著的升压作用。舒林酸具有升压作用这一事实表明，这种反应可能与抑制肾前列腺素无关，或者舒林酸的肾保护作用只是相对的。肾外前列腺素可能在该人群的血压控制中起作用。不稳定型或轻度高血压患者在使用这些NSAIDs治疗期间似乎未表现出过度的升压反应，因为正常受试者中也有类似的血压升高报道。
