Mahmoud I, Andia A, Marzouk I, Saidane O, Maatalah K, Tekaya R, Abdelmoula L
Faculté de médecine, université Tunis El Manar, Tunis, Tunisie; Service de rhumatologie, hôpital Charles-Nicolle, Tunis, Tunisie.
Faculté de médecine, université Tunis El Manar, Tunis, Tunisie; Service de rhumatologie, hôpital Charles-Nicolle, Tunis, Tunisie.
Rev Med Interne. 2016 Sep;37(9):639-43. doi: 10.1016/j.revmed.2015.12.013. Epub 2016 Jan 8.
We report a case of a particular lumbar and radicular pain revealing primary hyperparathyroidism and discuss its characteristics through a literature review.
A 55-year-old woman was hospitalized for a nerve root pain associated with recent weight loss with normal physical examination. Biology showed no evidence for acute phase response and normal kidney and liver functions. However, hypercalcemia and hypophosphatemia were evidenced. Radiographs of the lumbar spine showed a lytic lesion occupying the body of L4. A lumbar spine CT scan confirmed the presence of a compressive nerve root brown tumor. High level of PTH and parathyroid mass raised the possibility of the diagnosis of primary hyperparathyroidism. After parathyroidectomy all signs of hyperparathyroidism resolved with complete disappearance of spinal brown tumors in a two year follow-up CT scan.
Although uncommon, brown tumor should be a diagnosis to consider in their presence of a spinal tumor. The improvement after conservative treatment could be dramatic.
我们报告一例以特殊的腰腿痛为表现的原发性甲状旁腺功能亢进病例,并通过文献综述讨论其特点。
一名55岁女性因神经根性疼痛伴近期体重减轻入院,体格检查正常。生物学检查未显示急性期反应证据,肝肾功能正常。然而,发现有高钙血症和低磷血症。腰椎X线片显示L4椎体有溶骨性病变。腰椎CT扫描证实存在压迫神经根的棕色瘤。高水平的甲状旁腺激素和甲状旁腺肿物增加了原发性甲状旁腺功能亢进的诊断可能性。甲状旁腺切除术后,甲状旁腺功能亢进的所有体征均消失,在两年的随访CT扫描中脊柱棕色瘤完全消失。
尽管棕色瘤不常见,但在存在脊柱肿瘤时应考虑其诊断。保守治疗后的改善可能很显著。