School of Engineering, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland 4558, Australia.
Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.
Cell Death Dis. 2016 Jan 14;7(1):e2053. doi: 10.1038/cddis.2015.414.
Cell senescence is a cellular process in which normal diploid cells cease to replicate and is a major driving force for human cancers and aging-associated diseases. Recent studies on cell senescence have identified many new genetic components and pathways that control cell aging. However, there is no comprehensive resource for cell senescence that integrates various genetic studies and relationships with cell senescence, and the risk associated with complex diseases such as cancer is still unexplored. We have developed the first literature-based gene resource for exploring cell senescence genes, CSGene. We complied 504 experimentally verified genes from public data resources and published literature. Pathway analyses highlighted the prominent roles of cell senescence genes in the control of rRNA gene transcription and unusual rDNA repeat that constitute a center for the stability of the whole genome. We also found a strong association of cell senescence with HIV-1 infection and viral carcinogenesis that are mainly related to promoter/enhancer binding and chromatin modification processes. Moreover, pan-cancer mutation and network analysis also identified common cell aging mechanisms in cancers and uncovered a highly modular network structure. These results highlight the utility of CSGene for elucidating the complex cellular events of cell senescence.
细胞衰老（Cell senescence）是一种正常二倍体细胞停止复制的细胞过程，是人类癌症和衰老相关疾病的主要驱动力。最近对细胞衰老的研究确定了许多控制细胞衰老的新的遗传成分和途径。然而，目前还没有一个综合的细胞衰老资源，整合了各种遗传研究以及与细胞衰老的关系，而与癌症等复杂疾病相关的风险仍未得到探索。我们开发了第一个基于文献的探索细胞衰老基因的基因资源，即 CSGene。我们从公共数据资源和已发表的文献中整理了 504 个经过实验验证的基因。通路分析强调了细胞衰老基因在控制 rRNA 基因转录和构成整个基因组稳定性中心的异常 rDNA 重复方面的突出作用。我们还发现细胞衰老与 HIV-1 感染和病毒致癌作用之间存在很强的关联，这主要与启动子/增强子结合和染色质修饰过程有关。此外，泛癌症突变和网络分析还确定了癌症中常见的细胞衰老机制，并揭示了高度模块化的网络结构。这些结果突出了 CSGene 阐明细胞衰老复杂细胞事件的实用性。
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