Nucleic Acids Res. 2015 Jan;43(Database issue):D6-17. doi: 10.1093/nar/gku1130. Epub 2014 Nov 14.
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov.
美国国立生物技术信息中心(NCBI)提供了大量生物信息和数据的在线资源,包括GenBank®核酸序列数据库以及已发表生命科学期刊的文献引用和摘要数据库PubMed。NCBI的其他资源集中在文献方面(书架、PubMed中央数据库(PMC)和PubReader);医学遗传学方面(ClinVar、dbMHC、基因检测注册库、HIV-1/人类蛋白质相互作用数据库和MedGen);基因和基因组学方面(生物项目、生物样本、dbSNP、dbVar、表观基因组学、基因、基因表达综合数据库(GEO)、基因组、同源基因、图谱浏览器、核苷酸、种群数据集、探针、参考序列、序列读取存档、分类浏览器、追踪存档和单基因);以及蛋白质和化学物质方面(生物系统、COBALT、保守结构域数据库(CDD)、保守结构域架构检索工具(CDART)、分子建模数据库(MMDB)、蛋白质簇、蛋白质以及小分子数据库的PubChem套件)。Entrez系统为其中许多数据库提供搜索和检索操作。许多网络应用程序都增强了针对专门数据集进行搜索而优化的BLAST程序的定制实现。所有这些资源都可以通过NCBI主页(http://www.ncbi.nlm.nih.gov)访问。