Luostarinen V, Söderling E, Knuuttila M, Paunio K
J Periodontol. 1977 Jul;48(7):421-4. doi: 10.1902/jop.1977.48.7.421.
The application of chlorhexidine gluconate on the intact cheek pouch of hamsters led to an immediate increase of flow velocity determined in venules beneath the epithelium. The application of [14C]chlorhexidine on the intact cheek pouch led to accumulation of labeled material in the liver and kidneys. Both findings indicate that penetration of the drug occurred through the epithelium of the cheek pouch.
将葡萄糖酸氯己定应用于仓鼠完整的颊囊，导致上皮下小静脉中测定的血流速度立即增加。将[14C]氯己定应用于完整的颊囊，导致标记物质在肝脏和肾脏中积累。这两个发现均表明药物通过颊囊上皮渗透。
