Jilani Tanveer, Azam Iqbal, Moiz Bushra, Mehboobali Naseema, Perwaiz Iqbal Mohammad
1 Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
2 Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Int J Vitam Nutr Res. 2015;85(1-2):39-49. doi: 10.1024/0300-9831/a000222.
Hemoglobin levels slightly below the lower limit of normal are common in adults in the general population in developing countries. A few human studies have suggested the use of antioxidant vitamins in the correction of mild anemia. The objective of the present study was to investigate the association of vitamin E supplementation in mildly anemic healthy adults with post-supplemental blood hemoglobin levels in the general population of Karachi, Pakistan.
In a single-blinded and placebo-controlled randomized trial, 124 mildly anemic subjects from the General Practitioners' Clinics and personnel of the Aga Khan University were randomized into intervention (n = 82) and control (n = 42) group. In the intervention group, each subject was given vitamin E (400 mg) everyday for a period of three months, while control group subjects received a placebo. Eighty six subjects completed the trial. Fasting venous blood was collected at baseline and after three months of supplementation. Hemoglobin levels and serum/plasma concentrations of vitamin E, vitamin B12, folate, ferritin, serum transferrin receptor (sTfR), glucose, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, creatinine, total-antioxidant-status and erythropoietin were measured and analyzed using repeated measures ANOVA and multiple linear regression.
The adjusted regression coefficients (β) and standard error [SE(β)] of the significant predictors of post-supplemental hemoglobin levels were serum concentration of vitamin E (0.983[0.095]), gender (- 0.656[0.244]), sTfR (- 0.06[0.02]) and baseline hemoglobin levels (0.768[0.077]).
The study showed a positive association between vitamin E supplementation and enhanced hemoglobin levels in mildly anemic adults.
在发展中国家的普通人群中，血红蛋白水平略低于正常下限在成年人中很常见。一些人体研究表明，使用抗氧化维生素可纠正轻度贫血。本研究的目的是调查在巴基斯坦卡拉奇的普通人群中，轻度贫血的健康成年人补充维生素E与补充后血液血红蛋白水平之间的关联。
在一项单盲、安慰剂对照的随机试验中，来自全科医生诊所和阿迦汗大学的124名轻度贫血受试者被随机分为干预组（n = 82）和对照组（n = 42）。在干预组中，每位受试者每天服用维生素E（400毫克），持续三个月，而对照组受试者服用安慰剂。86名受试者完成了试验。在基线和补充三个月后采集空腹静脉血。测量并分析血红蛋白水平以及维生素E、维生素B12、叶酸、铁蛋白、血清转铁蛋白受体（sTfR）、葡萄糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、肌酐、总抗氧化状态和促红细胞生成素的血清/血浆浓度，采用重复测量方差分析和多元线性回归。
补充后血红蛋白水平的显著预测指标的调整回归系数（β）和标准误差[SE(β)]分别为维生素E血清浓度（0.983[0.095]）、性别（-0.656[0.244]）、sTfR（-0.06[0.02]）和基线血红蛋白水平（0.768[0.077]）。
该研究表明，轻度贫血成年人补充维生素E与血红蛋白水平升高之间存在正相关。
