School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai 200093; China.
Faculty of Pharmacy; Meijo University; 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503; Japan; Advanced Drug Delivery Group; Faculty of Pharmacy; The University of Sydney; Sydney; 2006, NSW, Australia.
Adv Drug Deliv Rev. 2016 May 1;100:102-15. doi: 10.1016/j.addr.2016.01.002. Epub 2016 Jan 11.
For inhalation drug delivery, amorphous powder formulations offer the benefits of increased bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and expanded options of using various drugs and their combinations. However, amorphous formulations usually have poor physicochemical stability. This review focuses on inhalable amorphous powders, including the production methods, the active pharmaceutical ingredients and the excipients with a highlight on stabilization of the particles.
对于吸入式药物输送，无定形粉末制剂为溶解度差的药物提供了提高生物利用度的好处，为生物制剂提供了改善的生化稳定性，并且扩大了使用各种药物及其组合的选择。然而，无定形制剂通常具有较差的物理化学稳定性。本综述重点介绍了可吸入的无定形粉末，包括生产方法、活性药物成分和赋形剂，并重点介绍了颗粒的稳定化。
