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Inotuzumab ozogamicin in adults with relapsed or refractory CD22-positive acute lymphoblastic leukemia: a phase 1/2 study.奥英妥珠单抗治疗复发或难治性CD22阳性成人急性淋巴细胞白血病：一项1/2期研究。
Blood Adv. 2017 Jun 27;1(15):1167-1180. doi: 10.1182/bloodadvances.2016001925.
2
Genomics in acute lymphoblastic leukaemia: insights and treatment implications.急性淋巴细胞白血病的基因组学：见解与治疗意义。
Nat Rev Clin Oncol. 2015 Jun;12(6):344-57. doi: 10.1038/nrclinonc.2015.38. Epub 2015 Mar 17.
3
Inotuzumab ozogamicin in B-cell acute lymphoblastic leukemias and non-Hodgkin's lymphomas.奥英妥珠单抗治疗B细胞急性淋巴细胞白血病和非霍奇金淋巴瘤。
Expert Opin Biol Ther. 2015 Apr;15(4):601-11. doi: 10.1517/14712598.2015.1024652.
4
Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody.使用CD22单克隆抗体奥英妥珠单抗治疗难治性和复发性急性淋巴细胞白血病患者的预后因素
Am J Hematol. 2015 Mar;90(3):193-6. doi: 10.1002/ajh.23901. Epub 2015 Jan 16.
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Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies.奥英妥珠单抗在血液系统恶性肿瘤中的临床前及临床开发
Mol Immunol. 2015 Oct;67(2 Pt A):107-16. doi: 10.1016/j.molimm.2014.09.014. Epub 2014 Oct 7.
6
Antibody-based therapies in B-cell lineage acute lymphoblastic leukaemia.B细胞系急性淋巴细胞白血病的抗体疗法
Eur J Haematol. 2015 Feb;94(2):99-108. doi: 10.1111/ejh.12408. Epub 2014 Aug 18.
7
Inotuzumab ozogamicin in the treatment of acute lymphoblastic leukemia.奥英妥珠单抗治疗急性淋巴细胞白血病
Front Biosci (Elite Ed). 2014 Jan 1;6(1):40-5. doi: 10.2741/e688.
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Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphoblastic leukemia.儿童复发 B 细胞急性淋巴细胞白血病患者应用 CMC-544（奥加米妥珠单抗）的初步经验。
Pediatr Blood Cancer. 2014 Feb;61(2):369-72. doi: 10.1002/pbc.24721. Epub 2013 Sep 2.
9
Novel targeted therapies in acute lymphoblastic leukemia.急性淋巴细胞白血病的新型靶向治疗
Leuk Lymphoma. 2014 Apr;55(4):737-48. doi: 10.3109/10428194.2013.823493. Epub 2013 Aug 28.
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Targeting CD22 in B-cell malignancies: current status and clinical outlook.靶向 B 细胞恶性肿瘤的 CD22：现状与临床展望。
BioDrugs. 2013 Aug;27(4):293-304. doi: 10.1007/s40259-013-0016-7.

奥英妥珠单抗在复发/难治性急性淋巴细胞白血病治疗中的作用。

Role of inotuzumab ozogamicin in the treatment of relapsed/refractory acute lymphoblastic leukemia.

作者信息

George Binsah, Kantarjian Hagop, Jabbour Elias, Jain Nitin

机构信息

Department of Leukemia, MD Anderson Cancer Centre, Houston, TX 77030, USA.

出版信息

Immunotherapy. 2016 Feb;8(2):135-43. doi: 10.2217/imt.15.108. Epub 2016 Jan 18.

DOI:10.2217/imt.15.108
PMID:26780449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618942/
Abstract

Inotuzumab ozogamicin is a humanized anti-CD22 monoclonal antibody bound to a toxic natural calicheamicin, which is under investigation for the treatment of relapsed/refractory acute lymphoblastic leukemia. CD22 is commonly expressed in 90-100% of malignant mature B-lymphocyte lineage. The first Phase II study with inotuzumab ozogamicin conducted by Kantarjian et al. gave the opportunity for heavily pretreated patients with acute lymphoblastic leukemia to go for allogeneic stem cell transplant. Inotuzumab is well-tolerated with the exception of veno-occlusive disease. Overall inotuzumab ozogamicin is potentially an encouraging and promising therapy for patients.

摘要

奥英妥珠单抗是一种与毒性天然加利车霉素结合的人源化抗CD22单克隆抗体，目前正用于复发性/难治性急性淋巴细胞白血病的治疗研究。CD22通常在90%-100%的恶性成熟B淋巴细胞谱系中表达。坎塔尔吉安等人进行的第一项关于奥英妥珠单抗的II期研究，为接受过大量预处理的急性淋巴细胞白血病患者提供了进行异基因干细胞移植的机会。除了静脉闭塞性疾病外，奥英妥珠单抗耐受性良好。总体而言，奥英妥珠单抗对患者来说可能是一种令人鼓舞且有前景的治疗方法。