芳烃受体途径的复杂性；通过多种蛋白质伴侣和DNA基序进行信号传导。
Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs.
作者信息
Jackson D P, Joshi A D, Elferink C J
出版信息
Toxicol Res (Camb). 2015 Sep 1;4(5):1143-1158. doi: 10.1039/c4tx00236a. Epub 2015 Mar 17.
Abstract
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.
摘要
芳烃受体是一种转录因子，它通过与多种蛋白质伴侣相互作用来调节基因表达；本文对这些相互作用进行了综述，包括涉及KLF6的新型NC-XRE途径。
相似文献
1
Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs.
Toxicol Res (Camb). 2015 Sep 1;4(5):1143-1158. doi: 10.1039/c4tx00236a. Epub 2015 Mar 17.
2
The tumor suppressor Kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner.
J Pharmacol Exp Ther. 2013 Jun;345(3):419-29. doi: 10.1124/jpet.113.203786. Epub 2013 Mar 19.
3
Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.
bioRxiv. 2025 May 22:2023.05.01.538985. doi: 10.1101/2023.05.01.538985.
4
A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt.
J Biol Chem. 1993 Oct 5;268(28):21002-6.
5
A novel nonconsensus xenobiotic response element capable of mediating aryl hydrocarbon receptor-dependent gene expression.
Mol Pharmacol. 2012 Mar;81(3):338-47. doi: 10.1124/mol.111.075952. Epub 2011 Nov 23.
6
Inhibitors of serine/threonine-specific protein phosphatases stimulate transcription by the Ah receptor/Arnt dimer by affecting a step subsequent to XRE binding.
Arch Biochem Biophys. 1997 Apr 1;340(1):73-82. doi: 10.1006/abbi.1997.9905.
7
Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.
J Biol Chem. 2003 Apr 25;278(17):15001-6. doi: 10.1074/jbc.M300645200. Epub 2003 Feb 3.
8
An inhibitory factor in rat thymus which interferes with binding of cytosol Ah receptor to xenobiotic responsive element.
Biochem Mol Biol Int. 1994 Aug;34(1):55-66.
9
Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene.
Mol Cell Biol. 1990 Dec;10(12):6408-16. doi: 10.1128/mcb.10.12.6408-6416.1990.
10
The same xenobiotic response element is required for constitutive and inducible expression of the mammalian aldehyde dehydrogenase-3 gene.
Arch Biochem Biophys. 1999 Jan 15;361(2):223-30. doi: 10.1006/abbi.1998.0989.
引用本文的文献
1
AhR signaling in skin-resident CD207 cells is involved in UV-B-induced amelioration of neuroinflammation.
Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2424009122. doi: 10.1073/pnas.2424009122. Epub 2025 Sep 2.
2
The Aryl Hydrocarbon Receptor in Neurotoxicity: An Intermediator Between Dioxins and Neurons in the Brain.
Toxics. 2025 Jul 16;13(7):596. doi: 10.3390/toxics13070596.
3
Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases.
Int J Mol Sci. 2024 Jun 25;25(13):6933. doi: 10.3390/ijms25136933.
4
The Role of Aryl Hydrocarbon Receptor in Bone Biology.
Int J Tryptophan Res. 2024 May 15;17:11786469241246674. doi: 10.1177/11786469241246674. eCollection 2024.
5
The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.
Int J Mol Sci. 2024 Apr 23;25(9):4599. doi: 10.3390/ijms25094599.
6
Implications of xenobiotic-response element(s) and aryl hydrocarbon receptor in health and diseases.
Hum Cell. 2023 Sep;36(5):1638-1655. doi: 10.1007/s13577-023-00931-5. Epub 2023 Jun 17.
7
Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.
Receptors (Basel). 2023 Mar;2(1):1-15. doi: 10.3390/receptors2010001. Epub 2023 Jan 4.
8
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation.
Cell Biosci. 2023 May 13;13(1):85. doi: 10.1186/s13578-023-01046-y.
9
The intestine: A highly dynamic microenvironment for IgA plasma cells.
Front Immunol. 2023 Feb 16;14:1114348. doi: 10.3389/fimmu.2023.1114348. eCollection 2023.
10
Aryl hydrocarbon receptor (AhR)-mediated signaling as a critical regulator of skeletal cell biology.
J Mol Endocrinol. 2022 Aug 22;69(3):R109-R124. doi: 10.1530/JME-22-0076. Print 2022 Oct 1.
本文引用的文献
1
Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene.
FASEB J. 2014 Dec;28(12):5262-76. doi: 10.1096/fj.14-251884. Epub 2014 Sep 11.
2
Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.
Int J Mol Sci. 2014 May 6;15(5):7939-57. doi: 10.3390/ijms15057939.
3
Functional analysis of the dioxin response elements (DREs) of the murine CYP1A1 gene promoter: beyond the core DRE sequence.
Int J Mol Sci. 2014 Apr 16;15(4):6475-87. doi: 10.3390/ijms15046475.
4
Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.
Toxicol Sci. 2014 Jul;140(1):135-43. doi: 10.1093/toxsci/kfu065. Epub 2014 Apr 9.
5
3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex.
PLoS One. 2014 Mar 21;9(3):e92793. doi: 10.1371/journal.pone.0092793. eCollection 2014.
6
The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation.
Eur J Immunol. 2014 May;44(5):1330-40. doi: 10.1002/eji.201343920. Epub 2014 Feb 18.
7
The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.
Toxicol Sci. 2014 May;139(1):121-32. doi: 10.1093/toxsci/kfu027. Epub 2014 Feb 11.
8
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
PLoS One. 2014 Feb 3;9(2):e87877. doi: 10.1371/journal.pone.0087877. eCollection 2014.
9
Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression.
Mol Pharmacol. 2014 Apr;85(4):533-41. doi: 10.1124/mol.113.089730. Epub 2014 Jan 15.
10
Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.
J Biol Chem. 2014 Jan 17;289(3):1866-75. doi: 10.1074/jbc.M113.505578. Epub 2013 Dec 3.
Zotero 插件