Mowery Todd M, Kotak Vibhakar C, Sanes Dan H
Center for Neural Science, New York University, 4 Washington Place, Room 810, New York, New York 10003, USA.
Nat Commun. 2016 Jan 20;7:10416. doi: 10.1038/ncomms10416.
Sensory systems influence one another during development and deprivation can lead to cross-modal plasticity. As auditory function begins before vision, we investigate the effect of manipulating visual experience during auditory cortex critical periods (CPs) by assessing the influence of early, normal and delayed eyelid opening on hearing loss-induced changes to membrane and inhibitory synaptic properties. Early eyelid opening closes the auditory cortex CPs precociously and dark rearing prevents this effect. In contrast, delayed eyelid opening extends the auditory cortex CPs by several additional days. The CP for recovery from hearing loss is also closed prematurely by early eyelid opening and extended by delayed eyelid opening. Furthermore, when coupled with transient hearing loss that animals normally fully recover from, very early visual experience leads to inhibitory deficits that persist into adulthood. Finally, we demonstrate a functional projection from the visual to auditory cortex that could mediate these effects.
感觉系统在发育过程中相互影响，剥夺会导致跨模态可塑性。由于听觉功能在视觉之前开始，我们通过评估早期、正常和延迟睁眼对听力损失引起的膜和抑制性突触特性变化的影响，来研究在听觉皮层关键期（CPs）操纵视觉经验的效果。早期睁眼会过早关闭听觉皮层关键期，而暗饲养可防止这种影响。相反，延迟睁眼会使听觉皮层关键期延长几天。从听力损失中恢复的关键期也会因早期睁眼而过早关闭，并因延迟睁眼而延长。此外，当与动物通常能完全恢复的短暂听力损失相结合时，非常早期的视觉经验会导致抑制性缺陷持续到成年期。最后，我们证明了从视觉皮层到听觉皮层的功能性投射，它可能介导这些影响。
