• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer.炎症反应基因的遗传变异及其与前列腺癌风险的关联。
Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
2
Association between genetic polymorphisms of inflammatory response genes and the risk of ovarian cancer.炎症反应基因的遗传多态性与卵巢癌风险之间的关联。
J Formos Med Assoc. 2016 Jan;115(1):31-7. doi: 10.1016/j.jfma.2015.01.002. Epub 2015 Feb 3.
3
Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese.NFKB1和NFKBIA基因多态性调节汉族人群患前列腺癌的风险。
Med Sci Monit. 2015 Jun 12;21:1707-15. doi: 10.12659/MSM.893471.
4
Association of common polymorphisms in TNFA, NFkB1 and NFKBIA with risk and prognosis of esophageal squamous cell carcinoma.常见的 TNFA、NFkB1 和 NFKBIA 多态性与食管鳞癌的风险和预后的关系。
PLoS One. 2013 Dec 4;8(12):e81999. doi: 10.1371/journal.pone.0081999. eCollection 2013.
5
Genetic polymorphisms in inflammatory response genes and their associations with breast cancer risk.炎症反应基因中的遗传多态性及其与乳腺癌风险的关联。
Croat Med J. 2014 Dec;55(6):638-46. doi: 10.3325/cmj.2014.55.638.
6
Association of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet's disease.NFKB1和NFKBIA基因多态性与白塞病易感性的关系
Scand J Immunol. 2015 Jan;81(1):81-6. doi: 10.1111/sji.12251.
7
Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population.NFKB1基因多态性影响土耳其人群桥本甲状腺炎患者血清白细胞介素-6的炎症水平。
Immunobiology. 2014 Jul;219(7):531-6. doi: 10.1016/j.imbio.2014.03.009. Epub 2014 Mar 20.
8
Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China.NFKB1和NFKBIA基因的遗传多态性与肝癌风险：中国上海的一项巢式病例对照研究。
BMJ Open. 2014 Feb 27;4(2):e004427. doi: 10.1136/bmjopen-2013-004427.
9
The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer.NFKB1 基因启动子区域的功能性-94 插入/缺失 ATTG 多态性增加了散发性结直肠癌的风险。
Cancer Epidemiol. 2013 Oct;37(5):634-8. doi: 10.1016/j.canep.2013.05.007. Epub 2013 Jun 24.
10
Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population.中国维吾尔族人群中NFKB1和NFKBIA基因变异与冠心病易感性
PLoS One. 2015 Jun 15;10(6):e0129144. doi: 10.1371/journal.pone.0129144. eCollection 2015.

引用本文的文献

1
Biosourcing and optimization of fungal lipase production from cheap agro waste via solid state fermentation.通过固态发酵从廉价农业废弃物中进行真菌脂肪酶生产的生物资源获取与优化。
Sci Rep. 2025 Jul 1;15(1):20967. doi: 10.1038/s41598-025-06505-9.
2
Genetic associations of prostate cancer in China: a systematic review.中国前列腺癌的遗传关联：一项系统综述。
BMC Cancer. 2025 Apr 3;25(1):604. doi: 10.1186/s12885-025-13830-9.
3
Inflammation-related indicators have a potential to increase overall quality of the prostate cancer management: a narrative review.炎症相关指标对提高前列腺癌管理的整体质量具有潜在作用：一项叙述性综述。
Transl Androl Urol. 2023 May 31;12(5):809-822. doi: 10.21037/tau-23-55. Epub 2023 May 8.
4
Impact of Gene-Environment Interactions on Cancer Development.基因-环境相互作用对癌症发展的影响。
Int J Environ Res Public Health. 2020 Nov 3;17(21):8089. doi: 10.3390/ijerph17218089.
5
Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer.复杂系统生物学方法在连接前列腺癌中的 PI3K-Akt 和 NF-κB 通路中的应用。
Cells. 2019 Feb 26;8(3):201. doi: 10.3390/cells8030201.
6
The association between -94ATTG ins/del and 826C/T genetic variations and coronary artery disease risk.-94ATTG插入/缺失与826C/T基因变异和冠状动脉疾病风险之间的关联。
Mol Biol Res Commun. 2018 Mar;7(1):17-24. doi: 10.22099/mbrc.2018.28261.1302.
7
NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies.NFKB1基因-94插入/缺失ATTG多态性与癌症风险：来自50项病例对照研究的证据。
Oncotarget. 2017 Feb 7;8(6):9806-9822. doi: 10.18632/oncotarget.14190.

本文引用的文献

1
The A55T and K153R polymorphisms of MSTN gene are associated with the strength training-induced muscle hypertrophy among Han Chinese men.MSTN 基因的 A55T 和 K153R 多态性与汉族男性力量训练引起的肌肉肥大有关。
J Sports Sci. 2014;32(9):883-91. doi: 10.1080/02640414.2013.865252. Epub 2014 Jan 30.
2
Association of common polymorphisms in TNFA, NFkB1 and NFKBIA with risk and prognosis of esophageal squamous cell carcinoma.常见的 TNFA、NFkB1 和 NFKBIA 多态性与食管鳞癌的风险和预后的关系。
PLoS One. 2013 Dec 4;8(12):e81999. doi: 10.1371/journal.pone.0081999. eCollection 2013.
3
Epidemiology of prostate cancer in the Asia-Pacific region.亚太地区前列腺癌的流行病学。
Prostate Int. 2013;1(2):47-58. doi: 10.12954/PI.12014. Epub 2013 Jun 30.
4
Cyclooxygenase 2 genotypes influence prostate cancer susceptibility in Japanese Men.环氧化酶2基因分型影响日本男性患前列腺癌的易感性。
Tumour Biol. 2014 Mar;35(3):2717-21. doi: 10.1007/s13277-013-1358-y. Epub 2013 Nov 8.
5
Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer.NFKBIA 启动子多态性与散发性结直肠癌风险的性别特异性关联。
Med Oncol. 2013 Dec;30(4):693. doi: 10.1007/s12032-013-0693-6. Epub 2013 Aug 31.
6
Polymorphisms in genes related to inflammation, NSAID use, and the risk of prostate cancer among Danish men.丹麦男性中与炎症、非甾体抗炎药使用及前列腺癌风险相关基因的多态性。
Cancer Genet. 2013 Jul-Aug;206(7-8):266-78. doi: 10.1016/j.cancergen.2013.06.001. Epub 2013 Jul 20.
7
The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer.NFKB1 基因启动子区域的功能性-94 插入/缺失 ATTG 多态性增加了散发性结直肠癌的风险。
Cancer Epidemiol. 2013 Oct;37(5):634-8. doi: 10.1016/j.canep.2013.05.007. Epub 2013 Jun 24.
8
Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features.NFKB1 和 NFKBIA 基因多态性对肝细胞癌易感性及临床病理特征的影响。
PLoS One. 2013;8(2):e56130. doi: 10.1371/journal.pone.0056130. Epub 2013 Feb 14.
9
Association of the innate immunity and inflammation pathway with advanced prostate cancer risk.先天免疫和炎症通路与晚期前列腺癌风险的关联。
PLoS One. 2012;7(12):e51680. doi: 10.1371/journal.pone.0051680. Epub 2012 Dec 14.
10
Genetic analysis of the principal genes related to prostate cancer: a review.前列腺癌主要相关基因的遗传分析：综述。
Urol Oncol. 2013 Nov;31(8):1419-29. doi: 10.1016/j.urolonc.2012.07.011. Epub 2012 Nov 7.

炎症反应基因的遗传变异及其与前列腺癌风险的关联。

Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer.

作者信息

Cui Xin, Yan Hao, Ou Tong-Wen, Jia Chun-Song, Wang Qi, Xu Jian-Jun

机构信息

Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

出版信息

Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.

DOI:10.1155/2015/674039
PMID:26788504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4691602/
Abstract

Prostate cancer is a common cancer in men. Genetic variations in inflammatory response genes can potentially influence the risk of prostate cancer. We aimed to examine the association between PPARG Pro12Ala, NFKB1 -94 ins/del, NFKBIA -826C/T, COX-1 (50C>T), and COX-2 (-1195G>A) polymorphisms on prostate cancer risk. The genotypes of the polymorphisms were ascertained in 543 prostate cancer patients and 753 controls through PCR-RFLP and the risk association was evaluated statistically using logistic regression analysis. The NFKB1 -94 polymorphism was shown to decrease prostate cancer risk in both heterozygous and homozygous comparison models (odds ratios of 0.74 (95% CI = 0.58-0.96) (P = 0.02) and 0.57 (95% CI = 0.42-0.78) (P < 0.01), resp.). An opposite finding was observed for COX-2 (-1195) polymorphism (odds ratios of 1.58 (95% CI = 1.15-2.18) (P < 0.01) for heterozygous comparison model and 2.08 (95% CI = 1.48-2.92) (P < 0.01) for homozygous comparison model). No association was observed for other polymorphisms. In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.

摘要

前列腺癌是男性常见的癌症。炎症反应基因的遗传变异可能会影响前列腺癌的风险。我们旨在研究PPARG Pro12Ala、NFKB1 -94插入/缺失、NFKBIA -826C/T、COX-1（50C>T）和COX-2（-1195G>A）多态性与前列腺癌风险之间的关联。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定了543例前列腺癌患者和753例对照的多态性基因型，并使用逻辑回归分析对风险关联进行了统计学评估。在杂合子和纯合子比较模型中，NFKB1 -94多态性均显示可降低前列腺癌风险（优势比分别为0.74（95%置信区间=0.58-0.96）（P=0.02）和0.57（95%置信区间=0.42-0.78）（P<0.01））。对于COX-2（-1195）多态性，观察到相反的结果（杂合子比较模型的优势比为1.58（95%置信区间=1.15-2.18）（P<0.01），纯合子比较模型的优势比为2.08（95%置信区间=1.48-2.92）（P<0.01））。未观察到其他多态性与前列腺癌的关联。总之，在中国人群中，NFKB1 -94插入/缺失和COX-2（-1195G>A）多态性可能分别与前列腺癌风险的降低和升高有关。