Korn S, Dehoratius R J
Department of Medicine, Hahnemann University School of Medicine, Philadelphia, Pennsylvania.
Am Fam Physician. 1989 Oct;40(4):243-6.
Methotrexate is an effective agent for the treatment of rheumatoid arthritis. It is now widely prescribed for patients who have not tolerated or responded to gold compounds or penicillamine. Minor adverse reactions are common, and fatal pulmonary toxicity or cirrhosis can occur. The drug does not produce disease remissions, but continued administration helps reduce pain, stiffness and swelling. Within the past year, the Food and Drug Administration has approved methotrexate for use in treating rheumatoid arthritis.
甲氨蝶呤是治疗类风湿性关节炎的一种有效药物。目前，它被广泛用于那些对金制剂或青霉胺不耐受或无反应的患者。轻微的不良反应很常见，也可能发生致命的肺部毒性或肝硬化。该药物不会使疾病缓解，但持续用药有助于减轻疼痛、僵硬和肿胀。在过去的一年里，美国食品药品监督管理局已批准甲氨蝶呤用于治疗类风湿性关节炎。
