Korotchikova Irina, Stevenson Nathan J, Livingstone Vicki, Ryan C Anthony, Boylan Geraldine B
Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland; Neonatal Unit, Cork University Maternity Hospital, Cork, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Clin Neurophysiol. 2016 Apr;127(4):2095-101. doi: 10.1016/j.clinph.2015.12.015. Epub 2015 Dec 22.
To examine sleep-wake cycle (SWC) composition of healthy term infants in the immediate postnatal period using EEG, and investigate factors that might influence it.
Multichannel video-EEG was recorded for a median of 61.9 min (IQR: 60.0-69.3). The absolute and relative scores of sleep states were calculated for each infant's recording. Parametric/non-parametric statistical tests and multiple linear regression analysis were used to investigate the influence of perinatal factors on SWC composition.
Eighty healthy term infants aged 1-36 h were studied. A well-developed SWC was evident as early as within the first 6h after birth. The mean (SD) percentage of active sleep (AS) was 52.1% (12.9) and quiet sleep (QS) was 38.6% (12.5). AS was longer and QS shorter in infants delivered by elective caesarean section (CS) compared to infants delivered by vaginal delivery or emergency CS.
This is the first large cohort EEG study that has quantified neonatal sleep. SWC is clearly present immediately after birth, it is dominated by AS, and is influenced by mode of delivery.
This knowledge of the early neonatal EEG/SWC can be used as reference data for EEG studies of neurologically compromised infants.
使用脑电图检查健康足月儿出生后即刻的睡眠-觉醒周期（SWC）组成，并调查可能影响它的因素。
多通道视频脑电图记录时间中位数为61.9分钟（四分位间距：60.0 - 69.3）。计算每个婴儿记录的睡眠状态的绝对和相对分数。使用参数/非参数统计检验和多元线性回归分析来研究围产期因素对SWC组成的影响。
研究了80名年龄在1 - 36小时的健康足月儿。早在出生后的前6小时内就明显存在发育良好的SWC。主动睡眠（AS）的平均（标准差）百分比为52.1%（12.9），安静睡眠（QS）为38.6%（12.5）。与经阴道分娩或急诊剖宫产的婴儿相比，择期剖宫产（CS）分娩的婴儿AS时间更长，QS时间更短。
这是第一项对新生儿睡眠进行量化的大型队列脑电图研究。SWC在出生后即刻明显存在，以AS为主导，并受分娩方式影响。
这种早期新生儿脑电图/SWC的知识可作为神经功能受损婴儿脑电图研究的参考数据。
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