Anderson C J, Gregory M C, Groggel G C, Clegg D O
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City.
Am J Kidney Dis. 1989 Oct;14(4):319-23. doi: 10.1016/s0272-6386(89)80213-6.
Reiter's syndrome is classically described as the triad of urethritis, conjunctivitis, and arthritis, It has many manifestations and has rarely been reported to occur in association with amyloidosis. Four cases of systemic amyloidosis have previously been reported. This case describes a patient who developed progressive renal amyloidosis after a 17-year history of severe Reiter's syndrome. Immunofluorescent staining of the renal biopsy was strongly positive for AA protein, the type of protein found in secondary amyloidosis. This is the first case in which amyloidosis has been proven to be secondary to Reiter's syndrome and not merely the coincidental occurrence of two rare diseases.
赖特综合征典型表现为尿道炎、结膜炎和关节炎三联征。它有多种表现形式，很少有与淀粉样变性相关的报道。此前曾报道过4例系统性淀粉样变性病例。本病例描述了一名患者，在患有严重赖特综合征17年后出现进行性肾淀粉样变性。肾活检的免疫荧光染色显示AA蛋白呈强阳性，AA蛋白是继发性淀粉样变性中发现的蛋白类型。这是首例被证实淀粉样变性继发于赖特综合征而非仅仅是两种罕见疾病巧合发生的病例。
