Wildgaard K, Ringsted T K, Hansen H J, Petersen R H, Kehlet H
Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.
Department of Thoracic Surgery, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2016 May;60(5):650-8. doi: 10.1111/aas.12681. Epub 2016 Jan 21.
The risk of persistent postsurgical pain (PPP) and subsequent pain-related functional impairment may potentially be reduced by video-assisted thoracic surgery (VATS) compared to thoracotomy. The aim of the study was therefore to assess in detail the incidence and consequences on activities of daily living of PPP after VATS.
Using a prospective observational design, 47 patients undergoing VATS completed both preoperative, early postoperative and 3 months follow-up. Preoperative pain, pain characteristics, psychological factors, pain-related functional impairment and quantitative sensory testing (QST) including nociceptive thresholds were compared with postoperative data.
Only five (11%) patients developed PPP with NRS > 3 originating from the surgical area. However, about 30% of patients still reported some pain-related functional impairment from the surgical area within four well-defined domains of everyday activities. Psychological and sensory thermal tests did not predict persistent postoperative pain, except preoperative pin-prick sensitivity was higher in patients with PPP. Postoperative pain 7 days after surgery was significantly higher in PPP patients. Preoperative pain originating from remote areas did not predict PPP.
The incidence of PPP, nerve damage (based on QST) and pain-related functional impairment following VATS was lower than reported following thoracotomy. No psychological or other factors predicted PPP. These findings call for further large-scale studies to support VATS to decrease PPP.
与开胸手术相比,电视辅助胸腔镜手术(VATS)可能会降低术后持续性疼痛(PPP)及随后与疼痛相关的功能障碍的风险。因此,本研究的目的是详细评估VATS术后PPP的发生率及其对日常生活活动的影响。
采用前瞻性观察设计,47例行VATS手术的患者完成了术前、术后早期及3个月随访。将术前疼痛、疼痛特征、心理因素、与疼痛相关的功能障碍以及包括伤害性阈值在内的定量感觉测试(QST)与术后数据进行比较。
只有5例(11%)患者出现了手术区域起源的数字评分量表(NRS)>3的PPP。然而,在日常活动的四个明确领域内,仍有大约30%的患者报告手术区域存在一些与疼痛相关的功能障碍。心理和感觉热测试不能预测术后持续性疼痛,除了PPP患者术前针刺敏感性较高。PPP患者术后7天的疼痛明显更高。术前源于远处区域的疼痛不能预测PPP。
VATS术后PPP的发生率、神经损伤(基于QST)及与疼痛相关的功能障碍低于开胸手术后报告的情况。没有心理或其他因素能预测PPP。这些发现需要进一步的大规模研究来支持VATS以降低PPP。