低剂量乙胺丁醇所致中毒性视神经病变的发病率
Incidence of toxic optic neuropathy with low-dose ethambutol.
作者信息
Yang H K, Park M J, Lee J-H, Lee C-T, Park J S, Hwang J-M
机构信息
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
出版信息
Int J Tuberc Lung Dis. 2016 Feb;20(2):261-4. doi: 10.5588/ijtld.15.0275.
OBJECTIVE
To investigate the incidence of ethambutol (EMB) induced optic neuropathy prescribed at a relatively low dose of ≤ 15 mg/kg/day for the treatment of tuberculosis (TB) or Mycobacterium avium complex (MAC) lung disease.
DESIGN
Patients diagnosed with TB or MAC lung disease received multidrug regimens including EMB at a single institution from August 2003 to July 2009. Visual monitoring was performed at baseline and at regular follow-up. The incidence of EMB-induced visual disturbances was evaluated.
RESULTS
Of the 415 patients included in the study, three (0.7%) developed toxic optic neuropathy over the 6-year period. Of the 289 patients prescribed a dose of ≤ 15 mg/kg/day EMB, only one (0.3%) developed toxic optic neuropathy.
CONCLUSIONS
The incidence of EMB-induced optic neuropathy among Koreans is estimated to be 0.7%, and can be reduced with lower doses of EMB.
目的
调查在治疗结核病（TB）或鸟分枝杆菌复合群（MAC）肺病时，使用相对低剂量（≤15mg/kg/天）乙胺丁醇（EMB）引发视神经病变的发生率。
设计
2003年8月至2009年7月期间，在单一机构中，被诊断为TB或MAC肺病的患者接受了包含EMB的多药治疗方案。在基线和定期随访时进行视力监测。评估EMB引起的视力障碍发生率。
结果
在纳入研究的415名患者中，6年期间有3名（0.7%）发生了中毒性视神经病变。在289名接受≤15mg/kg/天剂量EMB治疗的患者中，只有1名（0.3%）发生了中毒性视神经病变。
结论
韩国人中EMB诱发视神经病变的发生率估计为0.7%，较低剂量的EMB可降低该发生率。
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