喹硫平引起的持续性阴茎勃起需频繁急诊入院：病例报告
Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report.
作者信息
Jackson Jon C, Torrence Chasity L
机构信息
University of Mississippi Medical Center, Department of Psychiatry and Human Behavior, 2500 North State Street, Jackson, MS 39216, USA.
出版信息
Urol Case Rep. 2014 Oct 18;3(1):1-2. doi: 10.1016/j.eucr.2014.09.003. eCollection 2015 Jan.
Priapism, a rare but well-known adverse reaction of first and second generation anti-psychotics, has been hypothesized to be associated with blockade of alpha 1 receptors. However, genetic abnormalities or heritability of affected cytochrome P450 alleles has not been ruled out as a causal mechanism. A case is presented with three episodes of priapism within 17 days while taking standard FDA (Food and Drug Administration) approved doses of quetiapine. Cytochrome P450 3A4 genotype testing was performed and resulted with normal enzymatic activity. This case further eliminates enzymatic metabolism as a possible cause of priapism, thus strengthening the alpha one receptor blockade hypothesis.
阴茎异常勃起是第一代和第二代抗精神病药物一种罕见但广为人知的不良反应，据推测与α1受体阻断有关。然而，受影响的细胞色素P450等位基因的遗传异常或遗传性作为一种因果机制尚未被排除。本文报告了1例在服用美国食品药品监督管理局（FDA）批准的标准剂量喹硫平期间17天内发生3次阴茎异常勃起的病例。进行了细胞色素P450 3A4基因型检测，结果显示酶活性正常。该病例进一步排除了酶代谢作为阴茎异常勃起可能原因的可能性，从而强化了α1受体阻断假说。
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