狼疮发病机制：IgE自身抗体的作用
Lupus pathogenesis: role of IgE autoantibodies.
作者信息
Bayry Jagadeesh
机构信息
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, F-75006, France.
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France;
出版信息
Cell Res. 2016 Mar;26(3):271-2. doi: 10.1038/cr.2016.12. Epub 2016 Jan 22.
Abstract
IgE is commonly known for its role in the Th2 responses, protection against helminth parasites and pathogenesis of allergy. A recent report shows that IgE autoantibodies to dsDNA plays a major role in the pathogenesis of lupus nephritis by exacerbating the interferon-α responses in plasmacytoid dendritic cells.
摘要
IgE以其在Th2反应、抵御蠕虫寄生虫以及过敏发病机制中的作用而广为人知。最近的一份报告显示，针对双链DNA的IgE自身抗体通过加剧浆细胞样树突状细胞中的α干扰素反应，在狼疮性肾炎的发病机制中起主要作用。
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本文引用的文献
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Self-reactive IgE exacerbates interferon responses associated with autoimmunity.自身反应性IgE会加剧与自身免疫相关的干扰素反应。
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