聚乙二醇对用于药物应用的生物活性聚（ε-己内酯）熔体挤出物的力学和热性能的影响。

Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(ε-caprolactone) melt extrudates for pharmaceutical applications.

作者信息

Douglas P, Albadarin Ahmad B, Sajjia M, Mangwandi Chirangano, Kuhs Manuel, Collins Maurice N, Walker Gavin M

机构信息

School of Chemistry and Chemical Engineering, Queen's University Belfast BT9 5AG, Northern Ireland, UK.

School of Chemistry and Chemical Engineering, Queen's University Belfast BT9 5AG, Northern Ireland, UK; Solid State Pharmaceutical Centre (SSPC), Bernal Institute, Department of Chemical and Environmental Sciences, University of Limerick, Ireland.

出版信息

Int J Pharm. 2016 Mar 16;500(1-2):179-86. doi: 10.1016/j.ijpharm.2016.01.036. Epub 2016 Jan 18.

DOI:10.1016/j.ijpharm.2016.01.036

PMID:26794874

Abstract

This paper investigates the effects of polyethylene glycol (PEG), on the mechanical and thermal properties of nalidixic acid/poly ε-caprolactone (NA)/PCL blends prepared by hot melt extrusion. The blends were characterized by tensile and flexural analysis, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction. Results show that loading PEG in the PCL had a detrimental effect on the tensile strength and toughness of the blends, reducing them by 20-40%. The partial miscibility of the PCL-PEG system, causes an increase in Tg. While increases in the crystallinity is attributed to the plasticisation effect of PEG and the nucleation effect of NA. The average crystal size increased by 8% upon PEG addition. Experimental data indicated that the addition of NA caused loss of the tensile strength and toughness of PCL. Thermal analysis of the PCL showed that on addition of the thermally unstable NA, thermal degradation occurred early and was autocatalytic. However, the NA did benefit from the heat shielding provided by the PCL matrix resulting in more thermally stable NA particles.

摘要

本文研究了聚乙二醇（PEG）对通过热熔挤出制备的萘啶酸/聚ε-己内酯（NA）/PCL共混物的机械性能和热性能的影响。通过拉伸和弯曲分析、动态力学分析、差示扫描量热法、热重分析和X射线衍射对共混物进行了表征。结果表明，在PCL中加入PEG对共混物的拉伸强度和韧性有不利影响，使其降低了20-40%。PCL-PEG体系的部分互溶性导致玻璃化转变温度升高。而结晶度的增加归因于PEG的增塑作用和NA的成核作用。添加PEG后平均晶体尺寸增加了8%。实验数据表明，添加NA会导致PCL的拉伸强度和韧性下降。对PCL的热分析表明，加入热不稳定的NA后，热降解提前发生且具有自催化作用。然而，NA得益于PCL基体提供的热屏蔽，从而使NA颗粒具有更高的热稳定性。