Department of Surgery, Division of Plastic Reconstructive Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Department of Surgery, Division of Plastic Reconstructive Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Exp Neurol. 2017 Jan;287(Pt 3):331-347. doi: 10.1016/j.expneurol.2016.01.014. Epub 2016 Jan 18.
Rat models of complete and partial injuries are the most frequently used models for analysis of the cellular and molecular processes of nerve regeneration and axon sprouting. Studies of nerve regeneration and axon sprouting after complete and partial nerve injuries, respectively, are reviewed. Special consideration is made of the peripheral nerves chosen for the studies and the outcome measures that were utilized in the studies. The studies have made important contributions to our knowledge of the degenerative and regenerative processes that occur after the peripheral nerve injuries, why functional recovery is frequently compromised after delayed surgery, the positive effects of neurotrophic factors on nerve regeneration after delayed nerve repair or after insertion of autografts between transected nerve, and how axon regeneration may be accelerated by brief periods of electrical stimulation and/or by administration of androgens.
完全性和部分性损伤的大鼠模型是最常用于分析神经再生和轴突发芽的细胞和分子过程的模型。分别对完全性和部分性神经损伤后的神经再生和轴突发芽研究进行了综述。特别考虑了用于研究的周围神经和研究中使用的结果测量。这些研究为我们了解周围神经损伤后发生的退行性和再生过程、为什么延迟手术后功能恢复经常受到损害、神经营养因子对延迟神经修复或自体移植物插入切断神经之间后神经再生的积极影响，以及如何通过短暂的电刺激和/或雄激素给药加速轴突再生做出了重要贡献。
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