Duryodhan V S, Singh Abhimanyu, Singh Shiv Govind, Agrawal Amit
Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Indian Institute of Technology Hyderabad, Hyderabad 502205, India.
Sci Rep. 2016 Jan 22;6:18230. doi: 10.1038/srep18230.
Constant wall temperature /homogeneity in wall temperature is the need of various lab-on-chip devices employed in biological and chemical investigations. However method to maintain this condition does not seem to be available. In this work, a novel and simple way of maintaining constant wall temperature is proposed. A diverging microchannel along with conjugate effects is utilized towards this end. Both measurements and three dimensional numerical simulations are undertaken to prove the design. The investigation has been carried out over a large parameter range (divergence angle: 1-8°; length: 10-30 mm; depth: 86-200 μm; solid-to-fluid thickness ratio: 1.5-4.0, and solid-to-fluid thermal conductivity ratio: 27-646) and input conditions (mass flow rate: 4.17 × 10(-5) -9.17 × 10(-5) kg/s, heat flux: 2.4-9.6 W/cm(2)) which helped in establishing the finding. It is observed that a nearly constant wall temperature condition can be achieved over a large parameter range investigated. A model to arrive at the design parameter values is also proposed. The method is further demonstrated for series of microchannels where we successfully maintain each station at different temperature within ± 1 °C. The finding is therefore significant and can be employed in both single and multi-stage processes such as PCR requiring different constant wall temperature with a fine resolution.
恒定壁温/壁温均匀性是生物和化学研究中使用的各种芯片实验室设备的需求。然而,似乎没有维持这种条件的方法。在这项工作中,提出了一种新颖且简单的维持恒定壁温的方法。为此,利用了具有共轭效应的发散微通道。进行了测量和三维数值模拟以验证该设计。研究在较大的参数范围内(发散角:1 - 8°;长度:10 - 30 mm;深度:86 - 200 μm;固液厚度比:1.5 - 4.0,以及固液热导率比:27 - 646)和输入条件(质量流量:4.17×10⁻⁵ - 9.17×10⁻⁵ kg/s,热通量:2.4 - 9.6 W/cm²)下进行,这有助于确立研究结果。观察到在所研究的较大参数范围内可以实现近乎恒定的壁温条件。还提出了一个用于得出设计参数值的模型。该方法在一系列微通道中得到进一步验证,在这些微通道中,我们成功地将每个工位维持在不同温度且误差在±1°C 以内。因此,该发现具有重要意义,可应用于诸如 PCR 等需要不同恒定壁温且分辨率高的单级和多级过程中。