Laufer R, Changeux J P
URA, CNRS 0210 Département des Biotechnologies, Institut PASTEUR, Paris, France.
Mol Neurobiol. 1989 Spring-Summer;3(1-2):1-53. doi: 10.1007/BF02935587.
In both the central and the peripheral nervous systems, impulse activity regulates the expression of a vast number of genes that code for synaptic proteins, including neuropeptides, enzymes involved in neurotransmitter biosynthesis and degradation, and membrane receptors. In recent years, the mechanisms involved in these regulations became amenable to investigation by the methods of recombinant DNA technology. The first part of this review focuses on the activity-dependent control of nicotinic acetylcholine receptor biosynthesis in vertebrate muscle, a model case for the regulation of synaptic protein biosynthesis at the postsynaptic level. The second part summarizes some examples of neuronal proteins whose biosynthesis is under the control of transsynaptic impulse activity. The first, second, and third intracellular messengers involved in membrane-to-gene signaling are discussed, as are possible posttranscriptional control mechanisms. Finally, models are proposed for a role of neuronal activity in the genesis and stabilization of the synapse.
在中枢神经系统和外周神经系统中，冲动活动调节着大量编码突触蛋白的基因的表达，这些突触蛋白包括神经肽、参与神经递质生物合成和降解的酶以及膜受体。近年来，这些调节所涉及的机制已可用重组DNA技术的方法进行研究。本综述的第一部分着重于脊椎动物肌肉中烟碱型乙酰胆碱受体生物合成的活性依赖性控制，这是突触后水平上突触蛋白生物合成调节的一个典型例子。第二部分总结了一些神经元蛋白的例子，其生物合成受跨突触冲动活动的控制。文中讨论了参与膜到基因信号传导的第一、第二和第三细胞内信使，以及可能的转录后控制机制。最后，提出了神经元活动在突触发生和稳定中的作用模型。
