在联合抗逆转录病毒治疗时代感染 HIV 的肺癌患者。
Lung cancer in HIV-infected patients in the combination antiretroviral treatment era.
机构信息
1 Fundació Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Badalona, Spain ; 2 Universitat Autònoma de Barcelona (UAB), Barcelona, Spain ; 3 Medical Oncology Department, Catalan Institute of Oncology (ICO-Badalona), Hospital Universitari Germans Trias i Pujol, Badalona, Spain ; 4 Fundació IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Spain ; 5 Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Spain.
出版信息
Transl Lung Cancer Res. 2015 Dec;4(6):678-88. doi: 10.3978/j.issn.2218-6751.2015.08.10.
Abstract
The advent of combination antiretroviral treatment (cART) has been followed by a decrease in HIV-associated morbidity and mortality, but also by an apparent increase in the incidence of non-AIDS-defining cancers (NADCs). The risk of lung cancer is substantially higher in HIV-infected patients than in the general population, in part due to aging and tobacco use, and it is the most frequent NADC. The management of lung cancer in HIV-infected patients has some peculiarities that need to be taken into account. This review focuses on the epidemiology, risk factors, and clinical management of lung cancer in HIV-infected patients. In addition, screening tools and future perspectives are also discussed.
摘要
联合抗逆转录病毒治疗（cART）的出现降低了与 HIV 相关的发病率和死亡率，但也明显增加了非艾滋病定义性癌症（NADC）的发病率。与普通人群相比，HIV 感染者患肺癌的风险要高得多，部分原因是衰老和吸烟，而且肺癌也是最常见的 NADC。HIV 感染者肺癌的治疗有一些需要考虑的特殊性。本综述重点介绍了 HIV 感染者肺癌的流行病学、危险因素和临床管理。此外，还讨论了筛查工具和未来展望。
相似文献
1
Lung cancer in HIV-infected patients in the combination antiretroviral treatment era.在联合抗逆转录病毒治疗时代感染 HIV 的肺癌患者。
Transl Lung Cancer Res. 2015 Dec;4(6):678-88. doi: 10.3978/j.issn.2218-6751.2015.08.10.
2
Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico.墨西哥一家肿瘤三级护理中心的HIV感染患者中的非艾滋病定义性癌症（NADC）。
AIDS Res Ther. 2018 Oct 27;15(1):16. doi: 10.1186/s12981-018-0202-2.
3
Non--AIDS-defining malignancies in HIV.HIV患者中不定义为艾滋病相关的恶性肿瘤
Top HIV Med. 2008 Oct-Nov;16(4):117-21.
4
Burden of non-AIDS-defining and non-virus-related cancers among HIV-infected patients in the combined antiretroviral therapy era.联合抗逆转录病毒治疗时代HIV感染患者中不伴有艾滋病定义及非病毒相关癌症的负担
AIDS Res Hum Retroviruses. 2013 Aug;29(8):1097-104. doi: 10.1089/aid.2012.0321. Epub 2013 May 9.
5
The Pattern of Non-AIDS-defining Cancers in the HIV Population: Epidemiology, Risk Factors and Prognosis. A Review.HIV人群中未定义为艾滋病相关的癌症模式：流行病学、危险因素及预后。综述
Curr HIV Res. 2019;17(1):1-12. doi: 10.2174/1570162X17666190327153038.
6
Are Non-HIV Malignancies Increased in the HIV-Infected Population?HIV感染人群中非HIV相关恶性肿瘤的发病率是否增加？
Curr Infect Dis Rep. 2018 May 26;20(8):22. doi: 10.1007/s11908-018-0626-9.
7
A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients.前瞻性队列研究中 HIV 感染患者中非艾滋病定义性癌症的病例对照研究。
Med Clin (Barc). 2018 Apr 23;150(8):291-296. doi: 10.1016/j.medcli.2017.03.032. Epub 2017 May 18.
8
Non-AIDS-Defining Malignancies in the HIV-Infected Population.HIV 感染者中的非艾滋病定义性恶性肿瘤。
Curr Infect Dis Rep. 2014 Jun;16(6):406. doi: 10.1007/s11908-014-0406-0.
9
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts.艾滋病毒和癌症：巴西和美国临床队列的比较回顾性研究。
Infect Agent Cancer. 2015 Feb 2;10:4. doi: 10.1186/1750-9378-10-4. eCollection 2015.
10
The Trends and Risk Factors of AIDS-Defining Cancers and Non-AIDS-Defining Cancers in Adults Living with and without HIV: A Narrative Review.感染与未感染艾滋病毒的成年人中艾滋病定义性癌症和非艾滋病定义性癌症的趋势及风险因素：一项叙述性综述
J Cancer Epidemiol. 2024 Mar 21;2024:7588928. doi: 10.1155/2024/7588928. eCollection 2024.
引用本文的文献
1
The Trends and Risk Factors of AIDS-Defining Cancers and Non-AIDS-Defining Cancers in Adults Living with and without HIV: A Narrative Review.感染与未感染艾滋病毒的成年人中艾滋病定义性癌症和非艾滋病定义性癌症的趋势及风险因素：一项叙述性综述
J Cancer Epidemiol. 2024 Mar 21;2024:7588928. doi: 10.1155/2024/7588928. eCollection 2024.
2
HIV Associated Lung Cancer: Unique Clinicopathologic Features and Immune Biomarkers Impacting Lung Cancer Screening and Management.HIV 相关肺癌：影响肺癌筛查和管理的独特临床病理特征和免疫生物标志物。
Clin Lung Cancer. 2024 Mar;25(2):159-167. doi: 10.1016/j.cllc.2023.12.002. Epub 2023 Dec 12.
3
Prevalence of HPV-DNA and E6 mRNA in lung cancer of HIV-infected patients.人免疫缺陷病毒感染患者肺癌中 HPV-DNA 和 E6mRNA 的流行率。
Sci Rep. 2022 Aug 1;12(1):13196. doi: 10.1038/s41598-022-17237-5.
4
Latent infection screening and prevalence in cancer patients born outside of Australia: a universal versus risk-based approach?澳大利亚境外出生的癌症患者的潜伏感染筛查和流行率：普遍筛查与基于风险的筛查方法？
Support Care Cancer. 2021 Nov;29(11):6193-6200. doi: 10.1007/s00520-021-06116-w. Epub 2021 Mar 24.
5
Consensus study on the health system and patient-related barriers for lung cancer management in South Africa.南非肺癌管理的卫生系统及患者相关障碍的共识研究。
PLoS One. 2021 Feb 11;16(2):e0246716. doi: 10.1371/journal.pone.0246716. eCollection 2021.
6
Efavirenz induces DNA damage response pathway in lung cancer.依非韦伦可诱导肺癌中的DNA损伤反应通路。
Oncotarget. 2020 Oct 13;11(41):3737-3748. doi: 10.18632/oncotarget.27725.
7
Attitudes toward tobacco cessation and lung cancer screening in two South African communities.南非两个社区对戒烟和肺癌筛查的态度。
Glob Public Health. 2020 Oct;15(10):1537-1550. doi: 10.1080/17441692.2020.1761425. Epub 2020 May 14.
8
Immune Status and Associated Mortality After Cancer Treatment Among Individuals With HIV in the Antiretroviral Therapy Era.抗逆转录病毒治疗时代 HIV 感染者癌症治疗后的免疫状况和相关死亡率。
JAMA Oncol. 2020 Feb 1;6(2):227-235. doi: 10.1001/jamaoncol.2019.4648.
9
HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients.伴有间变性淋巴瘤激酶基因重排的HIV相关非小细胞肺癌：两例报告
Cureus. 2019 Aug 22;11(8):e5466. doi: 10.7759/cureus.5466.
10
Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients.细胞毒性化疗对抗逆转录病毒疗法抗病毒活性的不同影响：对HIV感染癌症患者治疗的启示。
Antivir Ther. 2019;24(3):177-186. doi: 10.3851/IMP3285.
本文引用的文献
1
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers.根据程序性死亡配体-1（PD-L1）的肿瘤表达情况，纳武单抗、派姆单抗和MPDL3280A的差异活性：黑色素瘤、肺癌和泌尿生殖系统癌症试验的敏感性分析
PLoS One. 2015 Jun 18;10(6):e0130142. doi: 10.1371/journal.pone.0130142. eCollection 2015.
2
Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since 2000.2010年法国HIV感染患者中与癌症相关的死亡原因：自2000年以来的演变
PLoS One. 2015 Jun 17;10(6):e0129550. doi: 10.1371/journal.pone.0129550. eCollection 2015.
3
Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States.美国HIV感染患者中癌症特异性死亡率升高
J Clin Oncol. 2015 Jul 20;33(21):2376-83. doi: 10.1200/JCO.2014.59.5967. Epub 2015 Jun 15.
4
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.纳武单抗与多西他赛治疗晚期鳞状细胞非小细胞肺癌的疗效比较
N Engl J Med. 2015 Jul 9;373(2):123-35. doi: 10.1056/NEJMoa1504627. Epub 2015 May 31.
5
Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.纳武单抗（抗程序性死亡1抗体，BMS-936558，ONO-4538）用于既往治疗过的晚期非小细胞肺癌患者的总生存期和长期安全性
J Clin Oncol. 2015 Jun 20;33(18):2004-12. doi: 10.1200/JCO.2014.58.3708. Epub 2015 Apr 20.
6
Pembrolizumab for the treatment of non-small-cell lung cancer.帕博利珠单抗治疗非小细胞肺癌。
N Engl J Med. 2015 May 21;372(21):2018-28. doi: 10.1056/NEJMoa1501824. Epub 2015 Apr 19.
7
Lung cancer incidence and survival among HIV-infected and uninfected women and men.感染和未感染艾滋病毒的女性及男性的肺癌发病率和生存率。
AIDS. 2015 Jun 19;29(10):1183-93. doi: 10.1097/QAD.0000000000000690.
8
A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal growth factor receptor mutations in lung cancer patients living with human immunodeficiency virus infection.一项关于感染人类免疫缺陷病毒的肺癌患者表皮生长因子受体突变的临床病理特征及分子流行病学的多机构研究。
J Cancer Res Clin Oncol. 2015 Sep;141(9):1669-78. doi: 10.1007/s00432-015-1956-8. Epub 2015 Mar 24.
9
Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options.PD-1共抑制通路在HIV感染中的作用及潜在治疗选择。
Retrovirology. 2015 Feb 8;12:14. doi: 10.1186/s12977-015-0144-x.
10
Survival among HIV-infected and HIV-uninfected individuals with common non-AIDS-defining cancers.感染HIV和未感染HIV的患有常见非艾滋病定义癌症个体的生存率。
Cancer Epidemiol Biomarkers Prev. 2015 Aug;24(8):1167-73. doi: 10.1158/1055-9965.EPI-14-1079. Epub 2015 Feb 24.
Zotero 插件