Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Department of Medical Physiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Int J Rheum Dis. 2017 Dec;20(12):2020-2027. doi: 10.1111/1756-185X.12791. Epub 2016 Jan 22.
We investigated the serum transforming growth factor beta 1 (TGFβ1) and fetuin-A levels, and determined the relationships between these biomarkers and disease activity, mobility and radiologic progression in patients with spondyloarthropathy (SpA) and rheumatoid arthritis (RA).
The study included 55 patients with SpA and 38 patients with RA, together with 28 healthy subjects. In AS patients, we assessed disease activity using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional ability using the Bath Ankylosing Spondylitis Functional Index (BASFI), and mobility using the Bath Ankylosing Spondylitis Metrology Index (BASMI), radiologic progression using the Bath Ankylosing Spondylitis Radiology Index (BASRI). Serum fetuin-A and TGFβ1 were determined using enzyme-linked immunosorbent assay (ELISA) equipment.
Fetuin-A was significantly higher in the axial SpA and RA groups than in healthy subjects (P < 0.01). Serum TGFβ1 and fetuin-A levels were similar in the peripheral SpA group and in healthy subjects. A significant positive correlation was found between the fetuin-A and TGFβ1 levels in the axial SpA, peripheral SpA, and RA groups (r = 0.293, P = 0.009; r = 0.215, P = 0.04; r = 0.223, P = 0.05, respectively). Significant correlations were found between fetuin-A and the BASMI and BASRI values in the axial SpA patients (r = 0.444, P = 0.031; r = 0.486, P < 0.001, respectively).
We conclude that Fetuin-A may be one of the steps that can be active in disease progression in axial SpA patients.
我们研究了血清转化生长因子β 1（TGFβ1）和胎球蛋白 A 水平，并确定了这些生物标志物与脊柱关节炎（SpA）和类风湿关节炎（RA）患者的疾病活动度、活动能力和放射学进展之间的关系。
本研究纳入了 55 例 SpA 患者和 38 例 RA 患者，以及 28 例健康对照者。在 AS 患者中，我们使用 Bath 强直性脊柱炎疾病活动指数（BASDAI）评估疾病活动度，使用 Bath 强直性脊柱炎功能指数（BASFI）评估功能能力，使用 Bath 强直性脊柱炎计量指数（BASMI）评估活动能力，使用 Bath 强直性脊柱炎放射学指数（BASRI）评估放射学进展。使用酶联免疫吸附试验（ELISA）设备测定血清胎球蛋白 A 和 TGFβ1。
轴性 SpA 和 RA 组的胎球蛋白 A 明显高于健康对照组（P < 0.01）。外周型 SpA 组与健康对照组的血清 TGFβ1 和胎球蛋白 A 水平相似。轴性 SpA、外周型 SpA 和 RA 组的胎球蛋白 A 与 TGFβ1 水平呈显著正相关（r = 0.293，P = 0.009；r = 0.215，P = 0.04；r = 0.223，P = 0.05）。轴性 SpA 患者的胎球蛋白 A 与 BASMI 和 BASRI 值呈显著相关（r = 0.444，P = 0.031；r = 0.486，P < 0.001）。
我们得出结论，胎球蛋白 A 可能是导致轴性 SpA 患者疾病进展的一个活跃步骤。
