Lee Eo G, Lee Hee J, Hyun Dong J, Min Kyunghoon, Kim Dong H, Yoon Moon S
Departments of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Departments of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Dermatol Ther. 2016 May;29(3):184-90. doi: 10.1111/dth.12331. Epub 2016 Jan 22.
Postherpetic neuralgia (PHN) is a sequela of herpes zoster that adversely affects quality of life seriously. The risk factors for PHN are well known but the effective interventions that reduce the incidence of PHN are less studied. The objective of this study is to evaluate the efficacy of treatment with gabapentin in patients with acute herpes zoster for preventing PHN. We performed a prospective randomized controlled study of 120 participants diagnosed with acute herpes zoster, aged 50 and over and complaining moderate to severe pain. All patients were treated with valacyclovir and acetaminophen. Half of the participants were assigned to the gabapentin group and received gabapentin 300 mg three times a day additionally. The intensity of pain at every visit and the incidence of PHN in both groups were measured. Total 52 and 49 patients in the gabapentin group and the control group, respectively, had completed 12 weeks of follow-up period. Although the incidence of PHN was higher in the control group, the difference was not statistically significant (6.1% vs. 3.8%, p = 0.67). Our results indicate that the use of low-dose gabapentin in acute herpes zoster seems not effective in the prevention of PHN.
带状疱疹后神经痛（PHN）是带状疱疹的一种后遗症，严重影响生活质量。PHN的危险因素已为人熟知，但减少PHN发病率的有效干预措施却鲜少被研究。本研究的目的是评估加巴喷丁治疗急性带状疱疹患者预防PHN的疗效。我们对120名年龄在50岁及以上、诊断为急性带状疱疹且主诉中重度疼痛的参与者进行了一项前瞻性随机对照研究。所有患者均接受伐昔洛韦和对乙酰氨基酚治疗。一半参与者被分配到加巴喷丁组，额外每天三次服用300毫克加巴喷丁。测量两组每次就诊时的疼痛强度和PHN的发病率。加巴喷丁组和对照组分别有52名和49名患者完成了12周的随访期。虽然对照组中PHN的发病率较高，但差异无统计学意义（6.1%对3.8%，p = 0.67）。我们的结果表明，在急性带状疱疹中使用低剂量加巴喷丁似乎对预防PHN无效。
