Babazade Rovnat, Turan Alparslan
a Department of Outcomes Research , Cleveland Clinic , Cleveland , OH , USA.
Expert Opin Drug Metab Toxicol. 2016;12(2):217-24. doi: 10.1517/17425255.2016.1134487. Epub 2016 Jan 22.
Intravenous patient-controlled analgesia using opioids is frequently used to provide perioperative analgesia. However, there are a number of drawbacks for intravenous patient-controlled analgesia. The sufentanil sublingual tablet system is a major evolution in technology and drug development for postoperative pain management.
We reviewed the use of sublingual sufentanil in postoperative pain management, with a focus on chemistry, pharmacokinetics and clinical use in different surgical patients.
The sufentanil sublingual tablet system can decrease intravenous patient-controlled analgesia-related safety issues. Current clinical studies have demonstrated this novel system to be safe and effective in postoperative pain management.
使用阿片类药物的静脉自控镇痛常用于提供围手术期镇痛。然而，静脉自控镇痛存在诸多缺点。舒芬太尼舌下片系统是术后疼痛管理技术和药物研发的一项重大进展。
我们回顾了舌下舒芬太尼在术后疼痛管理中的应用，重点关注其化学性质、药代动力学以及在不同手术患者中的临床应用。
舒芬太尼舌下片系统可减少与静脉自控镇痛相关的安全问题。目前的临床研究已证明这一新型系统在术后疼痛管理中安全有效。
