Fritel Xavier, Tsegan Yawo Edem, Pierre Fabrice, Saurel-Cubizolles Marie-Josèphe
Université de Poitiers, Faculté de Médecine et Pharmacie, INSERM CIC1402, Poitiers, France; CHU de Poitiers, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Poitiers, France; INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Gender, Sexual and Reproductive Health Team, Univ Paris-Sud, UMRS 1018, Kremlin-Bicêtre, France; Institut National des Etudes Démographiques, Paris, France.
INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne-Paris-Cité, DHU Risks in Pregnancy, Paris Descartes University, France.
Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:62-67. doi: 10.1016/j.ejogrb.2015.12.028. Epub 2016 Jan 8.
Our objective was to clarify whether de novo urinary incontinence (UI) in the postpartum period is associated with depressive symptoms or antidepressant drug consumption.
2002 pregnant women were recruited between 2003 and 2006 for the EDEN mother-child cohort. This analysis included 1413 women who reported no UI before pregnancy. Severity of UI was assessed by the Sandvik index. At 4 and 12 months postpartum, depressive symptoms were assessed by the Edinburgh Postpartum Depression Scale (EPDS≥10 defines depressive symptoms) and consumption of antidepressant drugs was reported.
At 4 months postpartum, 198 women (14%) reported de novo UI; 74% (n=146) reported mild UI, 26% (n=52) moderate, and none severe; prevalence of depressive symptoms was higher in women with than without UI (22.1% vs. 15.9%, p=0.045), and consumption of antidepressant drugs was more frequent (4.7% vs. 1.4%, p=0.005). At 12 months postpartum, the mean (±SD) EPDS score differed between women with than without UI (7.30±3.46 vs. 6.57±3.72, p=0.016) but was half that at 4 months postpartum. The incidence of new cases of depressive symptoms or antidepressant consumption at 12 months was greater with than without UI (23.8% vs. 15.3%, p=0.012).
Although UI is mild in most cases at 4 months postpartum, it is followed by more new cases of depressive symptoms or antidepressant consumption at 12 months.
我们的目的是阐明产后新发尿失禁(UI)是否与抑郁症状或抗抑郁药物的使用有关。
2003年至2006年期间,招募了2002名孕妇加入EDEN母婴队列。该分析纳入了1413名孕前无尿失禁的女性。通过桑德维克指数评估尿失禁的严重程度。在产后4个月和12个月时,通过爱丁堡产后抑郁量表评估抑郁症状(爱丁堡产后抑郁量表评分≥10定义为有抑郁症状),并记录抗抑郁药物的使用情况。
产后4个月时,198名女性(14%)报告新发尿失禁;74%(n = 146)报告为轻度尿失禁,26%(n = 52)为中度,无重度;有尿失禁的女性中抑郁症状的患病率高于无尿失禁的女性(22.1%对15.9%,p = 0.045),抗抑郁药物的使用也更频繁(4.7%对1.4%,p = 0.005)。产后12个月时,有尿失禁的女性与无尿失禁的女性相比,爱丁堡产后抑郁量表平均(±标准差)评分有所不同(7.30±3.46对6.57±3.72,p = 0.016),但仅为产后4个月时的一半。产后12个月时,有尿失禁的女性出现抑郁症状新病例或使用抗抑郁药物的发生率高于无尿失禁的女性(23.8%对15.3%,p = 0.012)。
虽然产后4个月时大多数尿失禁病例为轻度,但随后在12个月时会出现更多抑郁症状新病例或抗抑郁药物使用情况。