Rollino Cristiana, Vischini Gisella, Coppo Rosanna
SCDU Nefrologia e Dialisi, Ospedale S. G. Bosco, P.za Donatore di Sangue 3, 10154, Turin, Italy.
Divisione di Nefrologia, Fondazione Policlinico Gemelli, Università Cattolica, Rome, Italy.
J Nephrol. 2016 Aug;29(4):463-8. doi: 10.1007/s40620-016-0265-x. Epub 2016 Jan 22.
In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal handling of commensal microbes (gut microbiota). We also focus on particular infections reported in association with classic IgA nephropathy (HIV, malaria, Chlamydia, Lyme disease), as well as on IgA dominant-infection-associated glomerulonephritis. This is a unique form of glomerulonephritis, where IgA deposition is dominant. It is mostly recognized in old, diabetic patients and in association with staphylococcal infection.
在本文中，我们从发病机制和临床角度着重探讨感染在IgA肾病中的作用。目前关于感染在IgA肾病发病机制中的作用的假说有：（a）特定病原体的作用，（b）长期暴露于黏膜感染，（c）共生微生物（肠道微生物群）处理异常。我们还关注与经典IgA肾病相关的特定感染（HIV、疟疾、衣原体、莱姆病），以及IgA显性感染相关的肾小球肾炎。这是一种独特的肾小球肾炎形式，其中IgA沉积占主导。它多见于老年糖尿病患者，且与葡萄球菌感染有关。
