XBP1：葡萄糖和脂质代谢的关键转录调节因子。
XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism.
作者信息
Piperi Christina, Adamopoulos Christos, Papavassiliou Athanasios G
机构信息
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
出版信息
Trends Endocrinol Metab. 2016 Mar;27(3):119-122. doi: 10.1016/j.tem.2016.01.001. Epub 2016 Jan 20.
X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.
X盒结合蛋白1（XBP1）是未折叠蛋白反应（UPR）的一个主要且高度保守的组成部分，对葡萄糖稳态和脂质代谢至关重要。代谢功能障碍与XBP1转录活性有关。最近，选择性靶向IRE1α-XBP1途径的化合物已成为治疗代谢性疾病的一种潜在方法。
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