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[自膨式金属支架置入作为Ⅳ期梗阻性结直肠癌手术切除桥梁的分析]

[An Analysis of Placement of a Self-Expanding Metallic Stent as Bridge to Surgery for Surgical Resection of StageⅣ Obstructive Colorectal Cancers].

作者信息

Kawahara Yohei, Terada Itsuro, Terai Shiro, Watanabe Toshifumi, Amaya Koji, Yamamoto Seiichi, Kaji Masahide, Maeda Kiichi, Shimizu Koichi

机构信息

Dept. of Surgery, Toyama Prefectural Central Hospital.

出版信息

Gan To Kagaku Ryoho. 2015 Nov;42(12):1533-6.

Abstract

In our institution, placement of a self-expanding metallic stent (SEMS) for obstructive colorectal cancer to avoid emergency operations, namely as a bridge to surgery (BTS), was introduced in April 2012. Here, we assess the efficacy and safety of pre-operative SEMS placement for treatment of Stage Ⅳ obstructive colorectal cancer. We analyzed a total of 44 cases of Stage Ⅳ colorectal cancer, which consisted of 13 obstructive cases that were surgically resected following SEMS placement as BTS (BTS group), and 31 cases that were resected in elective operations without pre-operative SEMS placement (Ope group), from April 2012 to August 2014. None of the patients had any adverse events during the SEMS procedure or after SEMS placement, and all patients of BTS group could undergo the planned operations after sufficient decompression. In the postoperative period, 1 patient of BTS group (7.7%) had anastomosis bleeding, but no other complications, including anastomosis leakage, were observed in BTS group. However more progressive primary tumors were resected in BTS group (p=0.0115), there were no significant differences for post-operative course between the 2 groups; this indicated avoiding high-risk emergency operations contributed to adequate short-term outcomes in BTS group comparable to those in Ope group. SEMS placement as BTS could be performed safely for Stage Ⅳ obstructive colorectal cancer cases, and was 1 of the effective strategies for local treatment.

摘要

2012年4月,我院开始采用自膨式金属支架(SEMS)治疗梗阻性结直肠癌,以避免急诊手术,即作为手术桥梁(BTS)。在此,我们评估术前放置SEMS治疗Ⅳ期梗阻性结直肠癌的疗效和安全性。我们分析了2012年4月至2014年8月期间共44例Ⅳ期结直肠癌患者,其中13例梗阻性病例在放置SEMS作为BTS后接受了手术切除(BTS组),31例在未进行术前SEMS放置的择期手术中切除(手术组)。所有患者在SEMS置入过程中及置入后均未发生不良事件,BTS组所有患者在充分减压后均能接受计划中的手术。术后,BTS组有1例患者(7.7%)发生吻合口出血,但未观察到包括吻合口漏在内的其他并发症。然而,BTS组切除的进展期原发性肿瘤更多(p=0.0115),两组术后病程无显著差异;这表明避免高风险急诊手术有助于BTS组获得与手术组相当的短期良好结局。对于Ⅳ期梗阻性结直肠癌病例,将SEMS作为BTS放置可安全进行,且是局部治疗的有效策略之一。

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