[一例家族性腺瘤性息肉病患者发生子宫体、右卵巢及十二指肠癌的病例]

[A Case of Carcinoma of the Uterine Body, Right Ovary, and Duodenum in a Patient with Familial Adenomatous Polyposis].

作者信息

Ishibashi Keiichiro, Watanabe Yuichiro, Chika Noriyasu, Tajima Yusuke, Suzuki Okihide, Matsuzawa Takeaki, Kumamoto Kensuke, Fukuchi Minoru, Kumagai Yoichi, Baba Hiroyuki, Mochiki Erito, Iwama Takeo, Ishida Hideyuki

机构信息

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

出版信息

Gan To Kagaku Ryoho. 2015 Nov;42(12):1715-7.

PMID:26805148

Abstract

We report a case of 4 carcinomas of the uterine body, right ovary, and duodenum in a patient with familial adenomatous polyposis (FAP). Her mother's family line carries FAP. She underwent proctocolectomy with ileoanal anastomosis for FAP when she was 20 years old. She was diagnosed with carcinoma of the uterine body and right ovary, and underwent abdominal total hysterectomy, bilateral salpingo-oophorectomy, and omentectomy at 48 years of age. The pathological examination revealed endometrioid adenocarcinoma of the uterine body (Stage ⅠB) and endometrioid adenocarcinoma of the right ovary (Stage ⅠA). Her diagnosis was Stage Ⅳ according to the Spigelman classification of duodenal polyposis, and she underwent pancreas-preserving total duodenectomy at 50 years of age. The pathological examination was conclusive for 2 carcinomas in the adenoma, which were 20 mm and 25 mm in diameter, respectively. She has been well without any evidence of cancer recurrence 20 months after the pancreas-preserving total duodenectomy.

摘要

我们报告一例患有家族性腺瘤性息肉病（FAP）的患者，其子宫体、右卵巢和十二指肠发生了4处癌变。她母亲的家族携带FAP基因。她20岁时因FAP接受了直肠结肠切除术及回肠肛管吻合术。48岁时，她被诊断出子宫体癌和右卵巢癌，随后接受了腹式全子宫切除术、双侧输卵管卵巢切除术及大网膜切除术。病理检查显示子宫体子宫内膜样腺癌（ⅠB期）和右卵巢子宫内膜样腺癌（ⅠA期）。根据十二指肠息肉病的斯皮格尔曼分类，她的诊断为Ⅳ期，50岁时接受了保留胰腺的全十二指肠切除术。病理检查确诊腺瘤中有2处癌变，直径分别为20毫米和25毫米。在保留胰腺的全十二指肠切除术后20个月，她情况良好，没有任何癌症复发的迹象。