[家族性腺瘤性息肉病相关十二指肠腺瘤性息肉病中 Vater 乳头神经内分泌肿瘤 G1 例]

[A Case of NET G1 of Vater's Papilla in Familial Adenomatous Polyposis-Associated Duodenal Adenomatous Polyposis].

作者信息

Watanabe Yuichiro, Baba Hiroyuki, Fukuchi Minoru, Kumagai Youichi, Ishibashi Keiichiro, Mochiki Erito, Ishikawa Hideki, Ishida Hideyuki

机构信息

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

出版信息

Gan To Kagaku Ryoho. 2015 Nov;42(12):1764-6.

PMID:26805165

Abstract

INTRODUCTION

Familial adenomatous polyposis (FAP) is characterized by the development of duodenal polyposis (DP), which later develops into colonic adenomatous polyps and, eventually, colorectal cancer. Neuroendocrine tumors (NET) are rare in FAP and reports of pancreas-preserving total duodenectomy (PPTD) to treat NET are limited.

CASE

A 62-year-old. woman was previously diagnosed with FAP and she underwent a total colectomy and ileorectal anastomosis. Surveillance by upper gastrointestinal endoscopy revealed duodenal polyposis and a 35 mm flat, elevated tumor near the ampulla of Vater. She was diagnosed as having Spigelman stage Ⅳ DP and she underwent PPTD. Histopathology revealed a 7 mm NET G1 in the ampulla of Vater and multiple adenomas.

DISCUSSION

Little is known about duodenal NET G1in FAP patients who undergo PPTD. Close follow-up is necessary.

摘要

引言

家族性腺瘤性息肉病（FAP）的特征是十二指肠息肉病（DP）的发生，随后发展为结肠腺瘤性息肉，并最终发展为结直肠癌。神经内分泌肿瘤（NET）在FAP中较为罕见，关于保留胰腺的全十二指肠切除术（PPTD）治疗NET的报道有限。

病例

一名62岁女性，既往诊断为FAP，曾接受全结肠切除术和回肠直肠吻合术。上消化道内镜检查监测发现十二指肠息肉病以及在 Vater壶腹附近有一个35毫米的扁平、隆起性肿瘤。她被诊断为Spigelman Ⅳ期DP，并接受了PPTD。组织病理学检查显示在Vater壶腹有一个7毫米的G1级NET以及多个腺瘤。