普罗替林对正常受试者高碳酸血症和窒息通气反应的影响。

Effect of protriptyline on ventilatory responses to hypercapnia and asphyxia in normal subjects.

作者信息

Simonds A K, Carroll N, Branthwaite M A, Saunders N A

机构信息

Dept of Thoracic Medicine, Brompton Hospital, London.

出版信息

Eur Respir J. 1989 Sep;2(8):758-62.

PMID:2680583

Abstract

A double-blind crossover study was undertaken to assess the effect of protriptyline on ventilatory responses in normal subjects. Seven subjects received in random order placebo, 10 mg and 20 mg protriptyline daily for 2 weeks. Measurements of hypercapnic ventilatory response (HCVR) and asphyxial hypoxic ventilatory response (HVR) were made before treatment, 6-8 h after the first dose, and after 2 weeks treatment. Mean HCVR and HVR following 10 mg and 20 mg protriptyline did not differ significantly from measurements on placebo, neither for the single dose study or after 2 weeks.

摘要

进行了一项双盲交叉研究，以评估普罗替林对正常受试者通气反应的影响。7名受试者按随机顺序接受安慰剂、每日10毫克和20毫克普罗替林治疗，为期2周。在治疗前、首剂后6 - 8小时以及治疗2周后，测量高碳酸通气反应（HCVR）和窒息性低氧通气反应（HVR）。10毫克和20毫克普罗替林治疗后的平均HCVR和HVR与安慰剂测量值相比，无论是单剂量研究还是2周后，均无显著差异。