肥胖及采集方案对心脏交感神经支配的（123）I-间碘苄胍指标的影响
Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation.
作者信息
Pellegrino Teresa, Piscopo Valentina, Boemio Antonio, Russo Barbara, De Matteis Gianluca, Pellegrino Sara, Giorgio Sara Maria Delle Acque, Amato Manuela, Petretta Mario, Cuocolo Alberto
机构信息
1 Institute of Biostructure and Bioimaging, National Council of Research, Via De Amicis 95, 80145 Naples, Italy ; 2 Department of Advanced Biomedical Sciences, 3 Department of Translational Medical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.
出版信息
Quant Imaging Med Surg. 2015 Dec;5(6):822-8. doi: 10.3978/j.issn.2223-4292.2015.11.03.
BACKGROUND
This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation.
METHODS
Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar images of the thorax in anterior view were performed 15 minutes ("early" image) and 3 hours and 50 minutes ("late" image) after tracer administration in both supine- and prone-position. Early and late (123)I-MIBG heart-to-mediastinum (H/M) ratios and washout rate were computed.
RESULTS
In overall study population, early and late (123)I-MIBG H/M ratios and washout rate were comparable between supine- and prone-position acquisitions. Obese patients had a lower early and late (123)I-MIBG H/M ratios both in supine (P<0.01) and prone (P<0.05) positions compared to non-obese subjects.
CONCLUSIONS
Our results indicate that in HF patients, obesity has a significant impact on (123)I-MIBG indexes of cardiac sympathetic innervation. Prone-position did not change early and late (123)I-MIBG H/M ratios and washout rate compared to supine position both in obese and non-obese HF patients.
背景
本研究旨在评估肥胖及采集方案对心脏交感神经支配的碘-123间碘苄胍（MIBG）指标的影响。
方法
45例心力衰竭（HF）患者（38例男性，年龄58±15岁）接受了碘-123 MIBG心脏成像检查。其中10例为肥胖患者[体重指数（BMI）≥30 kg/m²]。在注射示踪剂后15分钟（“早期”图像）、3小时50分钟（“晚期”图像）分别于仰卧位和俯卧位采集胸部前位10分钟平面图像。计算早期和晚期碘-123 MIBG心/纵隔（H/M）比值及洗脱率。
结果
在整个研究人群中，仰卧位和俯卧位采集的早期和晚期碘-123 MIBG H/M比值及洗脱率相当。与非肥胖受试者相比，肥胖患者仰卧位（P<0.01）和俯卧位（P<0.05）的早期和晚期碘-123 MIBG H/M比值均较低。
结论
我们的结果表明，在心力衰竭患者中，肥胖对心脏交感神经支配的碘-123 MIBG指标有显著影响。与仰卧位相比，俯卧位并未改变肥胖和非肥胖心力衰竭患者的早期和晚期碘-123 MIBG H/M比值及洗脱率。
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