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吡咯:构建有价值治疗药物的新兴骨架。

Pyrrole: An emerging scaffold for construction of valuable therapeutic agents.

作者信息

Gholap Somnath S

机构信息

Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar (Loni kd.), Rahata, Ahmednagar, 413713, Maharashtra, India.

出版信息

Eur J Med Chem. 2016 Mar 3;110:13-31. doi: 10.1016/j.ejmech.2015.12.017. Epub 2015 Dec 13.

Abstract

Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics.

摘要

吡咯衍生物是一类具有生物活性的杂环化合物,可作为抗微生物、抗病毒、抗疟疾、抗结核、抗炎和酶抑制药物的有前景的骨架。由于其独特的抗癌和抗结核特性,研究人员受到启发,开发新型吡咯衍生物用于治疗多重耐药病原体。在本综述中,主要目标是关注吡咯模拟物的开发,并基于其构效关系(SAR)进行重点阐述。本综述对吡咯疗法的未来发展具有重要意义。

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