香港唐氏综合征儿童急性白血病：回顾性研究

Acute Leukemia in Down Syndrome Children in Hong Kong: Retrospective Review.

作者信息

Lam Grace Kee See, Leung Alex Wing Kwan, Ha Shau Yin, Luk Chung Wing, Li Chak Ho, Ling Siu Cheung, Chiang Alan Kwok Shing, Li Chi Kong

机构信息

*Department of Pediatrics, Prince of Wales Hospital, the Chinese University of Hong Kong †Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, the University of Hong Kong ‡Department of Pediatrics, Queen Elizabeth Hospital §Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital ∥Department of Pediatrics & Adolescent Medicine, Princess Margaret Hospital, Hong Kong.

出版信息

J Pediatr Hematol Oncol. 2016 Mar;38(2):102-6. doi: 10.1097/MPH.0000000000000500.

DOI:10.1097/MPH.0000000000000500

PMID:26808367

Abstract

BACKGROUND

Children with Down syndrome (DS) are at higher risk of developing acute leukemia. Treatment continues to evolve as we accumulate better understanding of the distinctive clinical and biological features of acute leukemia in DS patients.

PROCEDURE

A retrospective review of the clinical features, treatment outcomes, and survival of DS children with acute leukemia in Hong Kong from 1993 to 2013 was conducted. Patients were identified from the registry of the Hong Kong Pediatric Hematology and Oncology study group.

RESULTS

This cohort included a total of 29 patients with DS. Ten were diagnosed with acute lymphoblastic leukemia and 19 had acute myeloid leukemia (AML). The mean follow-up duration was 8.3 years (range, 0.6 mo to 18.1 y). The 5-year overall survival and event-free survival for DS-acute lymphoblastic leukemia and DS-AML were 65.6%, 54.9%, 89.5%, and 89.5%, respectively.

CONCLUSIONS

The clinical characteristics and treatment outcomes of DS patients with acute leukemia in Hong Kong were comparable with results from other international study groups. Patients with DS-AML had a better prognosis.

摘要