Peng Sufang, Yu Shunying, Wang Qian, Kang Qing, Zhang Yanxia, Zhang Ran, Jiang Wenhui, Qian Yiping, Zhang Haiyin, Zhang Mingdao, Xiao Zeping, Chen Jue
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Neurosci Lett. 2016 Mar 11;616:147-51. doi: 10.1016/j.neulet.2016.01.036. Epub 2016 Jan 22.
Dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) are important in dopamine system which is proved to be associated with food-anticipatory behavior, food restriction, reward and motivation. This has made them good candidates for anorexia nervosa (AN). The aim of this work is to explore the roles of DRD2 (rs1800497) and COMT (rs4680, rs4633, rs4818) gene polymorphisms in the susceptibility of AN within the Chinese Han population. We recruited 260AN patients with DSM-IV diagnosis criteria, and 247 unrelated, normal weight controls. DRD2 (rs1800497) and COMT (rs4680, rs4633, rs4818) were genotyped in all subjects. We found rs1800497 and rs4633 were associated with the susceptibility of AN within the Chinese Han sample, and allele C of rs1800497 was a protective factor. There was a gene-gene interaction between rs1800497 of DRD2 gene and rs4633 of COMT gene. We concluded that rs1800497 and rs4633 play important roles in the AN susceptibility with respect to the Chinese Han population. The gene-gene interaction between DRD2 and COMT contributes to the risk of AN.
多巴胺受体D2（DRD2）和儿茶酚-O-甲基转移酶（COMT）在多巴胺系统中起着重要作用，该系统已被证明与食物预期行为、食物限制、奖赏和动机有关。这使得它们成为神经性厌食症（AN）的良好候选研究对象。本研究的目的是探讨DRD2基因（rs1800497）和COMT基因（rs4680、rs4633、rs4818）多态性在中国汉族人群AN易感性中的作用。我们招募了260例符合DSM-IV诊断标准的AN患者，以及247名无亲缘关系的正常体重对照者。对所有受试者进行DRD2基因（rs1800497）和COMT基因（rs4680、rs4633、rs4818）的基因分型。我们发现rs1800497和rs4633与中国汉族样本中AN的易感性相关，rs1800497的C等位基因是一个保护因素。DRD2基因的rs1800497与COMT基因的rs4633之间存在基因-基因相互作用。我们得出结论，rs1800497和rs4633在中国汉族人群AN易感性中起重要作用。DRD2和COMT之间的基因-基因相互作用增加了AN的发病风险。
