珊瑚树树叶和嫩枝中的乌檀烷型二萜类化合物。

Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum.

作者信息

He Juan, Peng Li-Yan, Tu Lin, Wu Xing-De, Dong Liao-Bing, Pan Zheng-Hong, Chen Xuan-Qin, Su Jia, Zhao Yu, Xu Gang, Cheng Xiao, Li Yan, Zhao Qin-Shi

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.

Guangxi Institute of Botany, Chinese Academy of Science, Guilin 541006, China.

出版信息

Fitoterapia. 2016 Mar;109:224-9. doi: 10.1016/j.fitote.2016.01.014. Epub 2016 Jan 22.

DOI:10.1016/j.fitote.2016.01.014

PMID:26808916

Abstract

Seven new vibsane-type diterpenes, vibsanols C-H (1-6) and vibsanin X (7), together with seven analogues, were isolated from the leaves and twigs of Viburnum odoratissimum. The structures of the new compounds were elucidated by extensive spectroscopic methods. All the new compounds were detected for their cytotoxicity. Compound 1 showed significant cytotoxicity against all the tested cell lines (HL-60, SMMC-7721, A-594, MCF-7, and SW-480), with IC50 values of 3.35, 4.41, 5.18, 11.30, and 3.70 μM, respectively. Compounds 4 and 5 also displayed significant cytotoxicity against hepatocellular carcinoma SMMC-7721 cell line, with IC50 values of 3.69 and 3.52 μM, respectively.

摘要

从香荚蒾的叶和嫩枝中分离出7个新的维桑烷型二萜类化合物，即维桑醇C - H（1 - 6）和维桑宁X（7），以及7个类似物。通过广泛的光谱方法阐明了新化合物的结构。检测了所有新化合物的细胞毒性。化合物1对所有测试细胞系（HL - 60、SMMC - 7721、A - 594、MCF - 7和SW - 480）均显示出显著的细胞毒性，IC50值分别为3.35、4.41、5.18、11.30和3.70 μM。化合物4和5对肝癌SMMC - 7721细胞系也显示出显著的细胞毒性，IC50值分别为3.69和3.52 μM。