荚蒾三萜类和二萜类化合物。

Triterpenoids and diterpenoids from Viburnum chingii.

作者信息

Chen Xuan-Qin, Li Yan, He Juan, Cheng Xiao, Wang Kou, Li Ming-Ming, Pan Zheng-Hong, Peng Li-Yan, Zhao Qin-Shi

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(4):496-8. doi: 10.1248/cpb.59.496.

DOI:10.1248/cpb.59.496

PMID:21467682

Abstract

Two new oleanane triterpenoids (1-2) and one new vibsane-type diterpenoid (3), together with 7 known compounds (4-10), were isolated from the leaves of Viburnum chingii. The structures of compounds 1-3 were elucidated by means of spectroscopic methods including extensive 1D- and 2D-NMR technique. Cytotoxicity of compounds 1-10 were tested against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 3 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines.

摘要

从缙云荚蒾叶中分离得到两个新的齐墩果烷型三萜（1-2）和一个新的维伯烷型二萜（3），以及7个已知化合物（4-10）。采用包括广泛的一维和二维核磁共振技术在内的光谱方法阐明了化合物1-3的结构。测试了化合物1-10对HL-60、SMMC-7721、A-549、SK-BR-3和PANC-1细胞系的细胞毒性。化合物3对HL-60、SK-BR-3和PANC-1细胞系显示出显著的细胞毒性。