Ni Leng, Wang Zhanqi, Yang Genhuan, Li Tianjia, Liu Xinnong, Liu Changwei
Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
Toxicol Lett. 2016 Mar 14;245:99-105. doi: 10.1016/j.toxlet.2016.01.017. Epub 2016 Jan 22.
Cigarette smoke is not only a profound independent risk factor of atherosclerosis, but also aggravates restenosis after vascular angioplasty. Heme oxygenase-1 (HO-1) is an endogenous antioxidant and cytoprotective enzyme. In this study, we investigated whether HO-1 upregulating by hemin, a potent HO-1 inducer, can protect against cigarette smoke-induced restenosis in rat's carotid arteries after balloon injury. Results showed that cigarette smoke exposure aggravated stenosis of the lumen, promoted infiltration of inflammatory cells, and induced expression of inflammatory cytokines and adhesion molecules after balloon-induced carotid artery injury. HO-1 upregulating by hemin treatment reduced these effects of cigarette smoke, whereas the beneficial effects were abolished in the presence of Zincprotoporphyrin IX, an HO-1 inhibitor. To conclude, hemin has potential therapeutic applications in the restenosis prevention after the smokers' vascular angioplasty.
香烟烟雾不仅是动脉粥样硬化的一个重要独立危险因素，还会加重血管成形术后的再狭窄。血红素加氧酶-1（HO-1）是一种内源性抗氧化剂和细胞保护酶。在本研究中，我们调查了由强力HO-1诱导剂血红素上调的HO-1是否能预防大鼠颈动脉球囊损伤后香烟烟雾诱导的再狭窄。结果显示，暴露于香烟烟雾会加重球囊诱导的颈动脉损伤后的管腔狭窄，促进炎症细胞浸润，并诱导炎症细胞因子和黏附分子的表达。血红素处理上调HO-1可减轻香烟烟雾的这些作用，而在HO-1抑制剂锌原卟啉IX存在的情况下，这些有益作用消失。总之，血红素在预防吸烟者血管成形术后的再狭窄方面具有潜在的治疗应用价值。
