免疫抑制药物地塞米松在艰难梭菌感染期间与胃肠道微生物群转移相关的有害作用。
A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift.
作者信息
Kim Hyeun Bum, Wang Yuankai, Sun Xingmin
机构信息
Department of Infectious Disease and Global Health, Tufts University, North Grafton, MA 01536, USA.
Department of Animal Resource and Science, Dankook University, Cheonan, Chungnam 31116, Republic of Korea.
出版信息
J Microbiol Biotechnol. 2016 Mar;26(3):567-71. doi: 10.4014/jmb.1512.12017.
Abstract
We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.
摘要
我们在小鼠模型中研究了抗生素与免疫抑制药物联合使用导致艰难梭菌感染（CDI）风险增加的情况。我们的数据表明，抗生素治疗停止后数天内，肠道微生物群的情况大致恢复到治疗前状态，而抗生素与地塞米松联合治疗时，肠道微生物群的恢复则延迟，导致CDI严重程度增加。肠道微生物群的改变是CDI的关键因素。因此，我们的数据表明免疫抑制药物可通过延迟改变的肠道微生物群的恢复来增加CDI风险。
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