Olek Katarzyna, Kuczaj Agnieszka Anna, Warwas Szymon, Hrapkowicz Tomasz, Przybyłowski Piotr, Tanasiewicz Marta
Department of Dental Propedeutics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland.
Department of Cardiac Surgery, Transplantology, Vascular and Endovascular Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sklodowskiej 9, 41-800 Zabrze, Poland.
Biomedicines. 2023 May 30;11(6):1588. doi: 10.3390/biomedicines11061588.
The human gut microbiota include over 10 trillion microorganisms, such as bacteria, fungi, viruses, archaea, and protozoa. Many reports indicate the strong correlation between dysbiosis and the severity of cardiovascular diseases. Microbiota seem to interact with the host's alloimmunity and may have an immunomodulatory role in graft rejection processes. In our study, we present the current state of the knowledge of microbiota in heart transplant recipients. We present up-to-date microbiota diagnostic methods, interactions between microbiota and immunosuppressive drugs, the immunomodulatory effects of dysbiosis, and the available strategies (experimental and clinical strategies) to modulate host microbiota.
人类肠道微生物群包括超过10万亿种微生物，如细菌、真菌、病毒、古菌和原生动物。许多报告表明，生态失调与心血管疾病的严重程度之间存在密切关联。微生物群似乎与宿主的同种免疫相互作用，并且可能在移植物排斥过程中发挥免疫调节作用。在我们的研究中，我们展示了心脏移植受者微生物群的当前知识状况。我们介绍了最新的微生物群诊断方法、微生物群与免疫抑制药物之间的相互作用、生态失调的免疫调节作用，以及调节宿主微生物群的可用策略（实验性和临床策略）。
