Tomao Federica, Corrado Giacomo, Peccatori Fedro Alessandro, Boveri Sara, Preti Eleonora Petra, Colombo Nicoletta, Landoni Fabio
European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
University "Sapienza", Sapienza, Rome.
Curr Treat Options Oncol. 2016 Jan;17(1):5. doi: 10.1007/s11864-015-0386-9.
Cervical cancer (CC) is the fourth most frequent tumor and the fourth most common cause of cancer death among women worldwide. Furthermore, more than 40 % of women with early CC are affected during reproductive age and wish to remain fertile. Thus, many patients demand a more conservative policy for managing these lesions in order to have an uneventful pregnancy in the near future. For this reason, interest in fertility preservation strategies has been increasing, and the number of published studies on this topic has grown significantly. Conization was the first fertility-sparing surgical procedure tested in stage IA1 CC. However, in recent decades, other strategies have been tested, particularly for more advanced tumors. The aim of this review is to analyze the main techniques performed in patients with CC who are eligible for fertility-sparing surgery, with particular attention paid to open questions and controversies.
宫颈癌(CC)是全球女性中第四常见的肿瘤,也是癌症死亡的第四大常见原因。此外,超过40%的早期宫颈癌女性患者处于生育年龄,希望保留生育能力。因此,许多患者要求采取更保守的策略来处理这些病变,以便在不久的将来顺利怀孕。出于这个原因,对生育力保存策略的兴趣不断增加,关于这一主题的已发表研究数量也显著增长。锥切术是在IA1期宫颈癌中测试的第一种保留生育功能的外科手术。然而,在最近几十年里,已经测试了其他策略,特别是针对更晚期肿瘤的策略。本综述的目的是分析在适合保留生育功能手术的宫颈癌患者中所采用的主要技术,特别关注未解决的问题和争议。