Musa M G, Kagura J, Pisa P T, Norris S A
Department of Paediatrics,MRC/Wits Developmental Pathways for Health Research Unit,University of Witwatersrand Johannesburg,Gauteng,South Africa.
J Dev Orig Health Dis. 2016 Apr;7(2):132-43. doi: 10.1017/S2040174415007953. Epub 2016 Jan 26.
Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovascular disease risk factors in early adulthood. Adolescents (n=1935) from the Birth to Twenty plus (BT20+) cohort were included in the analysis. The following were treated as exposure variables: weight at birth, and relative conditional weight gain (CW), independent of height, between ages 0-24 months and 24-48 months. Outcomes were serum lipids and body composition variables at age 18 years. After adjusting for sex and other confounders, early life exposures were not associated with adolescent lipid profile. Following adjustment for sex and height (body size), birth weight [β=0.704 (0.40, 1.01)], CW 0-24 [β=1.918 (1.56, 2.28)] and CW24-48 [β=1.485 (1.14, 1.82)] accounted for 48% of the variance in fat mass. However, birth weight [β=0.773 (0.54, 1.01)], CW 0-24 [β=1.523 (1.24, 1.80)] and CW24-48 [β=1.226 (0.97, 1.49)] were also positively predicted and accounted for 71% of the variance in fat mass in adolescence (P<0.05). Our data suggests that birth weight and weight gain during infancy and early childhood independent of linear growth are related to adolescent body composition but not blood lipid profiles in an urban African population.
低出生体重以及幼儿期体重快速增加可能会导致日后患心血管疾病（如高血压和血脂异常）的风险增加。在本研究中，我们调查了出生时的体型、婴儿期和儿童期的相对体重增加与成年早期特定心血管疾病风险因素之间的关联。分析纳入了来自“从出生到二十岁以上”（BT20 +）队列的青少年（n = 1935）。以下因素被视为暴露变量：出生体重，以及0至24个月和24至48个月之间独立于身高的相对条件性体重增加（CW）。结局指标为18岁时的血脂和身体成分变量。在调整了性别和其他混杂因素后，早期生活暴露与青少年血脂谱无关。在调整了性别和身高（体型）后，出生体重[β = 0.704（0.40，1.01）]、0至24个月的CW[β = 1.918（1.56，2.28）]和24至48个月的CW[β = 1.485（1.14，1.82）]解释了体脂变化的48%。然而，出生体重[β = 0.773（0.54，1.01）]、0至24个月的CW[β = 1.523（1.24，1.80）]和24至48个月의CW[β = 1.226（0.97，1.49）]也呈正相关，且解释了青少年体脂变化的71%（P < 0.05）。我们的数据表明，在非洲城市人群中，独立于线性生长的出生体重以及婴儿期和幼儿期的体重增加与青少年身体成分有关，但与血脂谱无关。
