Walker Hayley E, Rosenberg Shoshana M, Stanton Annette L, Petrie Keith J, Partridge Ann H
1 Harvard Medical School , Boston, Massachusetts.
2 Dana-Farber Cancer Institute , Boston, Massachusetts.
J Adolesc Young Adult Oncol. 2016 Mar;5(1):16-23. doi: 10.1089/jayao.2015.0051. Epub 2015 Dec 17.
The aims of this study were to describe symptoms attributed to endocrine therapy (ET) and perceptions of ET in a sample of young women with breast cancer and to explore whether these factors are associated with adherence to ET.
An online questionnaire was completed by 106 young women taking ET for hormone receptor-positive breast cancer. In addition to demographic and medical characteristics, the survey assessed symptom attribution, emotions, and perceptions related to ET. A supplemental survey measuring adherence to ET was completed by 82/106 women. Means, medians, and frequency distributions were calculated for continuous and categorical covariates, respectively. An exploratory analysis evaluated whether adherence was associated with patient characteristics and views.
The mean age of respondents was 39 years (range 22-45 years). Two-thirds of women had stage 1 or 2 breast cancer. Women attributed an average of nine symptoms to ET; hot flashes, night sweats, and decreased libido were the most frequently attributed symptoms. Positive emotions toward ET were more common than negative emotions were, although only 48% of respondents believed that ET was essential. Women of higher financial status and those who reported more positive emotions toward ET reported greater adherence with ET. A significant difference in symptom attribution was not detected between less and more adherent respondents.
Young women's views regarding ET may play an important role in determining adherence behavior. Given that young women have a higher risk of recurrence, some of which may be attributable to ET non-adherence, further work is needed to confirm these findings and determine whether interventions designed to modify young women's perceptions of ET could promote adherence.
本研究旨在描述激素受体阳性乳腺癌年轻女性样本中归因于内分泌治疗（ET）的症状以及对ET的认知，并探讨这些因素是否与ET依从性相关。
106名接受ET治疗激素受体阳性乳腺癌的年轻女性完成了一份在线问卷。除人口统计学和医学特征外，该调查评估了与ET相关的症状归因、情绪和认知。82/106名女性完成了一项测量ET依从性的补充调查。分别计算连续和分类协变量的均值、中位数和频率分布。进行探索性分析以评估依从性是否与患者特征和观点相关。
受访者的平均年龄为39岁（范围22 - 45岁）。三分之二的女性患有1期或2期乳腺癌。女性平均将9种症状归因于ET；潮热、盗汗和性欲减退是最常归因的症状。对ET的积极情绪比消极情绪更常见，尽管只有48%的受访者认为ET至关重要。经济状况较好的女性以及对ET报告有更多积极情绪的女性报告的ET依从性更高。在依从性较低和较高的受访者之间未检测到症状归因的显著差异。
年轻女性对ET的看法可能在决定依从行为方面发挥重要作用。鉴于年轻女性复发风险较高，其中一些可能归因于ET不依从，需要进一步开展工作以证实这些发现，并确定旨在改变年轻女性对ET认知的干预措施是否能促进依从性。
