Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Breast. 2013 Oct;22(5):661-6. doi: 10.1016/j.breast.2013.05.005. Epub 2013 Jun 14.
BACKGROUND & STUDY AIMS: Adjuvant endocrine therapy effectively prevents recurrence and progression of estrogen-receptor positive breast cancer. However, studies reveal substantial non-adherence. The objective was therefore to identify the nature of the experiences and beliefs of women treated with endocrine therapy in an attempt to find potential determinants of non-adherence.
Online Focus Groups (OFGs) and individual interviews were conducted with 37 women who were treated with endocrine therapy. Sixty-three statements derived from the OFGs and 11 belief items from the Beliefs about Medicines Questionnaire (BMQ) were used in a Q-sorting task conducted with 14 of the women. The quantitative Q-sorting data were statistically analyzed with Hierarchical Cluster Analysis.
A six cluster solution was revealed that included the clusters 'information', 'efficacy', 'tenacity', 'coping', 'side effects' and 'usage'. Women's own experiences and perceptions were not clearly delineated from the beliefs measured with the BMQ. However, women judged their own experiences and perceptions with regard to endocrine therapy as more relevant for adherence than the BMQ beliefs.
In order to understand and to improve women's adherence to endocrine therapy, women's own perceptions and experiences about endocrine therapy should be targeted in addition to common beliefs that apply to a wide range of medicines.
辅助内分泌治疗能有效预防雌激素受体阳性乳腺癌的复发和进展。然而，研究显示存在大量的不依从性。因此，本研究旨在确定接受内分泌治疗的女性的体验和信念本质，试图找到不依从的潜在决定因素。
对 37 名接受内分泌治疗的女性进行了在线焦点小组（OFG）和个体访谈。从 OFG 中得出 63 条陈述和从药物信念问卷（BMQ）中得出 11 条信念项目，在与其中 14 名女性进行的 Q 分类任务中使用了这些陈述和项目。使用层次聚类分析对定量 Q 分类数据进行了统计分析。
揭示了一个六聚类解决方案，包括“信息”、“疗效”、“坚韧”、“应对”、“副作用”和“使用”聚类。女性自身的经验和认知与 BMQ 测量的信念并没有明确区分。然而，女性认为自己对内分泌治疗的经验和认知比 BMQ 信念更能决定其依从性。
为了理解和改善女性对内分泌治疗的依从性，除了针对广泛应用的药物的普遍信念外，还应针对女性自身对内分泌治疗的感知和经验进行靶向治疗。
