Szweda M, Szarek J, Lew M, Szarek-Bęska A, Gulda D
Pol J Vet Sci. 2015;18(4):793-8. doi: 10.1515/pjvs-2015-0103.
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were performed before and on the 21 day treatment with robenacoxib (1), robenacoxib, herbal solution with liquorice extract (2), placebo - an empty capsule (3). There were 5 animals in each group. The greatest microscopic damage in the colon was observed in animals which received robenacoxib. Plant drug administration reduced the severity of lesions in the colon when administered with robenacoxib (ARI = - 0.15).
concurrent administration of liquorice extract and plant solution with robenacoxib was associated with significant decreased severity of the robenacoxib-induced colonic mucosal lesions.
非甾体抗炎药（NSAIDs）常用于动物，尤其是犬类，以治疗炎性疾病引起的疼痛。本研究调查了植物药是否能预防罗贝考昔诱导的黏膜损伤。我们使用了15只4月龄的健康比格犬（7只雄性，8只雌性），研究开始时体重为4.2 - 5.1千克。在使用罗贝考昔（1）、罗贝考昔与含甘草提取物的草药溶液（2）、安慰剂——空胶囊（3）进行21天治疗之前及治疗期间，对结肠进行了内镜检查和活检。每组有5只动物。接受罗贝考昔的动物结肠出现了最严重的微观损伤。与罗贝考昔同时给药时，植物药可减轻结肠病变的严重程度（ARI = - 0.15）。
甘草提取物和植物溶液与罗贝考昔同时给药可显著降低罗贝考昔诱导的结肠黏膜损伤的严重程度。
