Zhang Xiaodong, Lin Jisheng, Yang Xiuquan, Fei Qi, Wang Bingqiang, Yang Yong, Li Jinjun, Ma Zhao, Zhao Fan, Wang Qi
Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
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Zhonghua Yi Xue Za Zhi. 2015 Nov 3;95(41):3366-9.
To investigate the osteoporosis prevalence and osteoporosis-related clinical risk factors among healthy elderly male.
A cross-sectional study was conducted from January 2014 to October 2014. Healthy elderly male aged 50 and above from Beijing WangZuo Community who had completed the questionnaire we made were enrolled in this study and accepted bone mineral density (BMD) testing by dual energy X-ray absorptiometry. Subjects were classified as the osteoporosis group (OP group) and the non-osteoporosis group (Non-OP group) according to the WHO criteria, of which osteoporosis was defined arbitrarily when any T-score was -2.5 standard deviations or less at femoral neck, total hip or lumbar spine (L1-4). The clinical risk factors of each subject including age, body weight, Body Mass Index (BMI), previous fragility fracture history, smoking, alcohol abuse, glucocorticoid therapy and other capable clinical risk factors were collected and compared in OP group and Non-OP group.
In the 346 cases of elderly healthy men, 18.5% had osteoporosis, 55.5% had osteopenia and 26.0% were normal. Femoral neck's and total hip's BMD level decreased with increasing age. However, the trend was not found at lumbar spine site. There appeared to be a significant difference in BMD standard between lumbar vertebral and total hip when compared with age-matched cohorts (P<0.05). Weight, BMI, previous fragility fracture history and smoking were found significant differences between OP group and Non-OP group (P<0.05).
The prevalence of osteoporosis in healthy older men should not be ignored. Low BMI and weight, previous fragility fracture history and smoking history were clinical risk factors of OP in this population.
调查健康老年男性骨质疏松症的患病率及骨质疏松相关临床危险因素。
于2014年1月至2014年10月进行一项横断面研究。纳入来自北京王佐社区、年龄在50岁及以上、完成自制问卷的健康老年男性，采用双能X线吸收法进行骨密度（BMD）检测。根据世界卫生组织标准，将受试者分为骨质疏松组（OP组）和非骨质疏松组（Non-OP组），当股骨颈、全髋或腰椎（L1-4）处的任何T值为-2.5标准差或更低时，任意定义为骨质疏松。收集并比较OP组和Non-OP组各受试者的临床危险因素，包括年龄、体重、体重指数（BMI）、既往脆性骨折史、吸烟、酗酒、糖皮质激素治疗及其他可能的临床危险因素。
在346例健康老年男性中，18.5%患有骨质疏松症，55.5%患有骨量减少，26.0%正常。股骨颈和全髋的BMD水平随年龄增加而降低。然而，在腰椎部位未发现此趋势。与年龄匹配的队列相比，腰椎和全髋的BMD标准存在显著差异（P<0.05）。体重、BMI、既往脆性骨折史和吸烟在OP组和Non-OP组之间存在显著差异（P<0.05）。
健康老年男性骨质疏松症的患病率不容忽视。低BMI和体重、既往脆性骨折史和吸烟史是该人群骨质疏松症的临床危险因素。
