• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血管修复治疗和生物可吸收血管支架。

Vascular restoration therapy and bioresorbable vascular scaffold.

机构信息

National Engineering Research Center For Biomaterials, Sichuan University, Chengdu 610064, China.

出版信息

Regen Biomater. 2014 Nov;1(1):49-55. doi: 10.1093/rb/rbu005. Epub 2014 Oct 20.

DOI:10.1093/rb/rbu005
PMID:26816624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4669005/
Abstract

This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s, metallic bare metal stent and metallic drug-eluting stent technologies in 1990s and 2000s, to bioresorbable vascular scaffold (BVS) technology in large-scale development in recent years. The history, the current stage, the challenges and the future of BVS development are discussed in detail as the best available approach for vascular restoration therapy. The criteria of materials selection, design and processing principles of BVS, and the corresponding clinical trial results are also summarized in this article.

摘要

本文描述了血管修复治疗的微创介入技术从 20 世纪 70 年代的早期球囊血管成形术，到 90 年代和 21 世纪的金属裸支架和药物洗脱支架技术，再到近年来大规模发展的生物可吸收血管支架（BVS）技术的演变历程。作为血管修复治疗的最佳方法，本文详细讨论了 BVS 的历史、现状、挑战和未来。本文还总结了 BVS 的材料选择标准、设计和加工原理以及相应的临床试验结果。

相似文献

1
Vascular restoration therapy and bioresorbable vascular scaffold.血管修复治疗和生物可吸收血管支架。
Regen Biomater. 2014 Nov;1(1):49-55. doi: 10.1093/rb/rbu005. Epub 2014 Oct 20.
2
Comparison of in vivo acute stent recoil between the bioresorbable everolimus-eluting coronary scaffolds (revision 1.0 and 1.1) and the metallic everolimus-eluting stent.比较生物可吸收依维莫司洗脱冠状动脉支架（修订版 1.0 和 1.1）与金属依维莫司洗脱支架的体内急性支架回缩。
Catheter Cardiovasc Interv. 2011 Jul 1;78(1):3-12. doi: 10.1002/ccd.22864. Epub 2011 Mar 16.
3
Absorb bioresorbable vascular scaffold versus everolimus-eluting metallic stent in ST-segment elevation myocardial infarction: 1-year results of a propensity score matching comparison: the BVS-EXAMINATION Study (bioresorbable vascular scaffold-a clinical evaluation of everolimus eluting coronary stents in the treatment of patients with ST-segment elevation myocardial infarction).生物可吸收血管支架与依维莫司洗脱金属支架治疗 ST 段抬高型心肌梗死：倾向评分匹配比较的 1 年结果：BVS-EXAMINATION 研究（生物可吸收血管支架——依维莫司洗脱冠状动脉支架治疗 ST 段抬高型心肌梗死患者的临床评估）。
JACC Cardiovasc Interv. 2015 Jan;8(1 Pt B):189-197. doi: 10.1016/j.jcin.2014.10.005.
4
The Current Literature on Bioabsorbable Stents: a Review.生物可吸收支架的最新文献综述。
Curr Atheroscler Rep. 2019 Nov 25;21(12):54. doi: 10.1007/s11883-019-0816-4.
5
Incidence and short-term clinical outcomes of small side branch occlusion after implantation of an everolimus-eluting bioresorbable vascular scaffold: an interim report of 435 patients in the ABSORB-EXTEND single-arm trial in comparison with an everolimus-eluting metallic stent in the SPIRIT first and II trials.在 ABSORB-EXTEND 单臂试验中，435 例患者接受依维莫司洗脱生物可吸收血管支架治疗后小分支闭塞的发生率及短期临床结局：与 SPIRIT 试验 I 和 II 中依维莫司洗脱金属支架的比较。
JACC Cardiovasc Interv. 2013 Mar;6(3):247-57. doi: 10.1016/j.jcin.2012.10.013.
6
Patient profile and periprocedural outcomes of bioresorbable vascular scaffold implantation in comparison with drug-eluting and bare-metal stent implantation. Experience from ORPKI Polish National Registry 2014-2015.生物可吸收血管支架植入与药物洗脱支架及裸金属支架植入相比的患者资料及围手术期结果。来自2014 - 2015年波兰国家心血管介入注册中心（ORPKI）的经验。
Postepy Kardiol Interwencyjnej. 2016;12(4):321-328. doi: 10.5114/aic.2016.63632. Epub 2016 Nov 17.
7
A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial.生物可吸收依维莫司洗脱支架与金属依维莫司洗脱支架治疗初发原生冠状动脉病变所致缺血性心脏病的比较（ABSORB II）：一项随机对照临床试验的临床和操作次要终点 1 年中期分析。
Lancet. 2015 Jan 3;385(9962):43-54. doi: 10.1016/S0140-6736(14)61455-0. Epub 2014 Sep 14.
8
Incidence and imaging outcomes of acute scaffold disruption and late structural discontinuity after implantation of the absorb Everolimus-Eluting fully bioresorbable vascular scaffold: optical coherence tomography assessment in the ABSORB cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions).植入可吸收依维莫司洗脱完全生物可吸收血管支架后急性支架断裂和晚期结构不连续性的发生率和影像学结果：ABSORB 队列 B 试验的光学相干断层成像评估（生物可吸收依维莫司洗脱冠状动脉支架系统治疗初发原生冠状动脉病变患者的临床评价）。
JACC Cardiovasc Interv. 2014 Dec;7(12):1400-11. doi: 10.1016/j.jcin.2014.06.016.
9
Bioresorbable vascular scaffold versus everolimus-eluting stents or drug eluting balloon for the treatment of coronary in-stent restenosis: 1-Year follow-up of a propensity score matching comparison (the BIORESOLVE-ISR Study).生物可吸收血管支架与依维莫司洗脱支架或药物洗脱球囊治疗冠状动脉支架内再狭窄的比较：倾向性评分匹配比较的 1 年随访（BIORESOLVE-ISR 研究）。
Catheter Cardiovasc Interv. 2018 Oct 1;92(4):668-677. doi: 10.1002/ccd.27473. Epub 2018 Jan 22.
10
Comparison of everolimus- and biolimus-eluting coronary stents with everolimus-eluting bioresorbable vascular scaffolds: Two-year clinical outcomes of the EVERBIO II trial.依维莫司洗脱冠状动脉支架和生物雷帕霉素洗脱冠状动脉支架与依维莫司洗脱生物可吸收血管支架的比较：EVERBIO II试验的两年临床结果。
Int J Cardiol. 2017 Sep 15;243:121-125. doi: 10.1016/j.ijcard.2017.05.053. Epub 2017 May 12.

引用本文的文献

1
A novel paclitaxel eluting bioresorbable vascular stent with a super flexible stent structure and round cross section struts fabricated using 3D printing technology with a rotating platform.一种新型的紫杉醇洗脱生物可吸收血管支架，具有超灵活的支架结构和圆形横截面支柱，采用带有旋转平台的3D打印技术制造。
Regen Biomater. 2025 Jul 9;12:rbaf073. doi: 10.1093/rb/rbaf073. eCollection 2025.
2
Development of 4D-Printed Arterial Stents Utilizing Bioinspired Architected Auxetic Materials.利用仿生结构负泊松比材料开发4D打印动脉支架
Biomimetics (Basel). 2025 Jan 26;10(2):78. doi: 10.3390/biomimetics10020078.
3
A comprehensive study on venous endovascular management and stenting in deep veins occlusion and stenosis: A review study.深静脉闭塞和狭窄的静脉血管腔内治疗与支架置入综合研究：一项综述研究
Surg Open Sci. 2024 Apr 16;19:131-140. doi: 10.1016/j.sopen.2024.04.001. eCollection 2024 Jun.
4
A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues.一种由定制胶原蛋白功能化的无药物心血管支架可支持血管组织的原位愈合。
Nat Commun. 2024 Jan 25;15(1):735. doi: 10.1038/s41467-024-44902-2.
5
Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents.用于下一代心血管支架开发的制造技术进展
J Funct Biomater. 2023 Nov 10;14(11):544. doi: 10.3390/jfb14110544.
6
An extracellular matrix-mimetic coating with dual bionics for cardiovascular stents.一种具有双重仿生学特性的用于心血管支架的细胞外基质模拟涂层。
Regen Biomater. 2023 May 30;10:rbad055. doi: 10.1093/rb/rbad055. eCollection 2023.
7
PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization.聚左旋乳酸复合材料与生物活性剂递送系统结合用于抗炎和再内皮化
Pharmaceutics. 2022 Nov 30;14(12):2661. doi: 10.3390/pharmaceutics14122661.
8
Strategies for Enhancing Polyester-Based Materials for Bone Fixation Applications.增强聚酯基材料在骨固定应用中的策略。
Molecules. 2021 Feb 13;26(4):992. doi: 10.3390/molecules26040992.
9
immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages.镁对单核细胞向抗炎性巨噬细胞的免疫调节作用。
Regen Biomater. 2020 Aug;7(4):391-401. doi: 10.1093/rb/rbaa010. Epub 2020 Apr 14.
10
Automated Segmentation of Bioresorbable Vascular Scaffold Struts in Intracoronary Optical Coherence Tomography Images.冠状动脉光学相干断层扫描图像中生物可吸收血管支架支柱的自动分割
Int Conf Bioinform Biomed Eng. 2017 Oct;2017:297-302. doi: 10.1109/BIBE.2017.00-38. Epub 2018 Jan 11.

本文引用的文献

1
Lumen gain and restoration of pulsatility after implantation of a bioresorbable vascular scaffold in porcine coronary arteries.生物可吸收血管支架植入猪冠状动脉后管腔获得和搏动恢复。
JACC Cardiovasc Interv. 2014 Jun;7(6):688-95. doi: 10.1016/j.jcin.2013.11.024. Epub 2014 May 14.
2
Bioresorbable metal scaffold for cardiovascular application: current knowledge and future perspectives.用于心血管应用的生物可吸收金属支架：当前认知与未来展望。
Cardiovasc Revasc Med. 2014 Mar;15(2):109-16. doi: 10.1016/j.carrev.2014.01.011. Epub 2014 Jan 30.
3
Evolution of implantable and insertable drug delivery systems.植入式和可插入式药物输送系统的发展。
J Control Release. 2014 May 10;181:1-10. doi: 10.1016/j.jconrel.2014.02.006. Epub 2014 Feb 15.
4
Bioresorbable scaffolds: rationale, current status, challenges, and future.可吸收支架：原理、现状、挑战与未来
Eur Heart J. 2014 Mar;35(12):765-76. doi: 10.1093/eurheartj/eht542. Epub 2013 Dec 23.
5
Short-term safety and efficacy of the biodegradable iron stent in mini-swine coronary arteries.可生物降解铁支架在小型猪冠状动脉中的短期安全性和有效性。
Chin Med J (Engl). 2013;126(24):4752-7.
6
Six-month IVUS and two-year clinical outcomes in the EVOLVE FHU trial: a randomised evaluation of a novel bioabsorbable polymer-coated, everolimus-eluting stent.EVOLVE FHU 试验的 6 个月血管内超声和两年临床结局：一种新型可生物吸收聚合物涂层、依维莫司洗脱支架的随机评估。
EuroIntervention. 2013 Jul;9(3):308-15. doi: 10.4244/EIJV9I3A52.
7
A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial.靶向研究 I 试验：新型无内膜凹槽填充型可生物降解聚合物西罗莫司洗脱支架与持久性聚合物依维莫司洗脱支架的随机比较：临床和血管造影随访结果
EuroIntervention. 2013 May 20;9(1):75-83. doi: 10.4244/EIJV9I1A12.
8
Process of prototyping coronary stents from biodegradable Fe-Mn alloys.从可生物降解的 Fe-Mn 合金中制作冠状动脉支架的过程。
Acta Biomater. 2013 Nov;9(10):8585-92. doi: 10.1016/j.actbio.2013.04.027. Epub 2013 May 7.
9
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.暴露于可生物降解铁基合金的小鼠成纤维细胞的基因表达谱用于支架。
Acta Biomater. 2013 Nov;9(10):8746-53. doi: 10.1016/j.actbio.2013.02.033. Epub 2013 Mar 14.
10
Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial.无聚合物涂层雷帕霉素洗脱支架与紫杉醇洗脱支架治疗冠状动脉旁路移植术后患者的疗效比较：一项随机、开放标签、非劣效性试验
Lancet. 2013 Feb 23;381(9867):661-9. doi: 10.1016/S0140-6736(12)61962-X. Epub 2013 Jan 30.